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Elderly lung transplant recipients show acceptable long-term outcomes for lung transplantation: A propensity score-matched analysis

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Abstract

Purpose

Although the performance lung transplantation (LTx) in the elderly (≥ 60 years) has increased globally, the situation in Japan remains quite different, because the age limit at registration for cadaveric transplantation is 60 years. We investigated the long-term outcomes of LTx in the elderly in Japan.

Methods

This was a single-center retrospective study. We divided the patients into two groups according to age: the younger group (< 60 years; Y group; n = 194) and the elderly group (≥ 60 years; E group; n = 10). We performed three-to-one propensity score matching to compare the long-term survival between the E and Y groups.

Results

In the E group, the survival rate was significantly worse (p = 0.003), and single-LTx was more frequent (p = 0.036). There was a significant difference in the indications for LTx between the two groups (p < 0.001). The 5-year survival rate after single-LTx in the E group was significantly lower than that in the Y group (p = 0.006). After propensity score matching, the 5-year survival rates of the two groups were comparable (p = 0.55). However, the 5-year survival rate after single-LTx in the E group was significantly lower than that in the Y group (p = 0.007).

Conclusion

Elderly patients showed acceptable long-term survival after LTx.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

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Authors and Affiliations

  1. Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan

    Yasuaki Tomioka, Toshio Shiotani, Kentaroh Miyoshi, Mikio Okazaki, Masaomi Yamane & Shinichi Toyooka

  2. Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital, 2-5-1 Shikata-Cho, Kita-Ku, Okayama, 700-8558, Japan

    Shin Tanaka & Seiichiro Sugimoto

  3. Department of Cardiovascular and Thoracic Surgery, Ehime University Medical School, Toon City, Japan

    Shinji Otani

  4. Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

    Haruchika Yamamoto

Authors
  1. Yasuaki Tomioka
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  2. Shin Tanaka
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  3. Shinji Otani
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  4. Toshio Shiotani
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  5. Haruchika Yamamoto
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  6. Kentaroh Miyoshi
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  7. Mikio Okazaki
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  8. Seiichiro Sugimoto
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  9. Masaomi Yamane
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  10. Shinichi Toyooka
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Contributions

YT, ST., and SO. designed the study. YT and ST. analyzed the data. SO. performed the statistical analysis. YT and ST drafted and revised the article. All authors critically edited the manuscript and approved the final version.

Corresponding author

Correspondence to Shin Tanaka.

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The authors declare no conflicts of interest in association with the present study.

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Tomioka, Y., Tanaka, S., Otani, S. et al. Elderly lung transplant recipients show acceptable long-term outcomes for lung transplantation: A propensity score-matched analysis. Surg Today 53, 1286–1293 (2023). https://doi.org/10.1007/s00595-023-02699-5

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  • DOI: https://doi.org/10.1007/s00595-023-02699-5

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