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Prophylactic supraclavicular lymph node dissection for esophageal squamous cell carcinoma: a systematic review and meta-analysis

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Abstract

The supraclavicular lymph nodes (SCLNs) have been regarded as regional nodes for esophageal squamous cell carcinoma (ESCC) in Japan and eastern Asian countries, whereas their involvement has been regarded as distant metastasis in Western countries. The importance of thorough dissection of the lymphatic chain along the recurrent laryngeal nerve, including the cervical paraesophageal nodes, has become well understood; therefore, the contemporary clinical question is whether prophylactic SCLN dissection (SLND) in addition to cervical paraesophageal node dissection is beneficial for patients with ESCC. We analyzed studies comparing esophagectomy with SLND vs. esophagectomy without SLND, in both of which cervical paraesophageal node dissection had been completed, based on a comprehensive literature search of the PubMed, Scopus, and Cochrane databases. Our meta-analysis focused on two long-term outcomes: 3-year and 5-year overall survival (OS) rates; and three short-term outcomes: pneumonia, recurrent nerve palsy, and anastomotic leakage. Four studies, with a collective total of 1584 patients were included in the review. No significant differences were found between esophagectomy with SLND vs. esophagectomy without SLND in the meta-analysis of both long-term (3-year and 5-year OS; risk ratio 1.09, 95% CI 0.94–1.26, P = 0.28, and risk ratio 1.14, 95% CI 0.96–1.35, P = 0.15, respectively) and short-term outcomes. Based on our analysis, no clear data support prophylactic SLND on the cervical paraesophageal node dissection.

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Authors and Affiliations

  1. Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Shigeru Tsunoda, Nobuaki Hoshino, Shinya Yoshida & Kazutaka Obama

  2. Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University Hospital, Kyoto, Japan

    Nobuaki Hoshino

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  1. Shigeru Tsunoda
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  2. Nobuaki Hoshino
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  3. Shinya Yoshida
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  4. Kazutaka Obama
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Contributions

ST and NH contributed to the study concept and design. Literature search and data collection were performed by NH and SY. Statistical analysis was conducted by NH and SY and then checked by the other authors. The first draft of the manuscript was written by ST, and all authors commented on the previous version of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Shigeru Tsunoda.

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Appendices

Appendix S1

Search strategy for pubmed

#1 "Esophageal Neoplasms"[MeSH Terms].

#2 esophagus[Tiab] OR esophageal[Tiab] OR oesophagus[Tiab] OR oesophageal[Tiab].

#3 neoplasm[Tiab] OR cancer[Tiab] OR tumor[Tiab] OR carcinoma[Tiab].

#4 #2 AND #3

#5 #1 OR #4

#6 three-field[Tiab] OR 3-field[Tiab] OR supraclavicular[Tiab] OR cervical[Tiab] OR neck[Tiab] OR extensive[Tiab] OR extended[Tiab].

#7 "Lymph Node Excision"[MeSH Terms].

#8 dissection[Tiab] OR lymphadenectomy[Tiab].

#9 #7 OR #8

#10 #6 AND #9

#11 #5 AND #10

#12 #11 AND english[la].

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Tsunoda, S., Hoshino, N., Yoshida, S. et al. Prophylactic supraclavicular lymph node dissection for esophageal squamous cell carcinoma: a systematic review and meta-analysis. Surg Today 53, 647–654 (2023). https://doi.org/10.1007/s00595-022-02544-1

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  • DOI: https://doi.org/10.1007/s00595-022-02544-1

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