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Association of lower limb ischemia with loss of skeletal muscle mass in patients with peripheral artery disease

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Abstract

Purpose

The influence of lower limb ischemia on the loss of skeletal muscle mass, which is a prerequisite for sarcopenia, remains poorly studied in patients with peripheral artery disease (PAD). We determined whether or not lower limb ischemia correlates with a loss of skeletal muscle mass in patients with PAD.

Methods

The data of 101 patients (202 legs) with PAD were retrospectively analyzed. Body composition was measured using a bioelectrical impedance analysis. Based on the Asian Working Group for Sarcopenia, low muscle mass (LMM) was defined as skeletal muscle mass index (SMI) < 7.00 kg/m2 (male) and < 5.70 kg/m2 (female). Both univariable and multivariable analyses of the risk factors for LMM were performed.

Results

There were significant differences in age, ankle-brachial pressure index (ABI) per patient, and the geriatric nutritional risk index (GNRI), between patients with and without LMM. Multivariable logistic regression analysis showed age (odds ratio [OR], 1.09; p = 0.009), GNRI (OR, 0.93; p = 0.003), and ABI per patient (OR, 0.02; p = 0.027) as independent risk factors for LMM.

Conclusion

These data show a detrimental effect of lower limb ischemia on skeletal muscle mass loss, suggesting that PAD may affect the development of secondary sarcopenia.

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Data availability

The deidentified participant data will not be shared.

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Toshiya Nishibe, Tomomi Kusakabe & Shoji Fukuda

  2. Department of Surgery, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

  3. Department of Surgery, Eniwa Midorino Clinic, Eniwa, Japan

    Masayasu Nishibe

  4. Department of Radiology, Chiba University School of Medicine, Chiba, Japan

    Jun Koizumi

Authors
  1. Toshiya Nishibe
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  2. Alan Dardik
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  3. Tomomi Kusakabe
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  4. Shoji Fukuda
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  5. Masayasu Nishibe
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  6. Jun Koizumi
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Correspondence to Toshiya Nishibe.

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Nishibe, T., Dardik, A., Kusakabe, T. et al. Association of lower limb ischemia with loss of skeletal muscle mass in patients with peripheral artery disease. Surg Today 52, 1576–1581 (2022). https://doi.org/10.1007/s00595-022-02500-z

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  • DOI: https://doi.org/10.1007/s00595-022-02500-z

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