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Prediction of lymph node metastasis of clinical stage IA non-small cell lung cancer based on the tumor volume doubling time

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Abstract

Purpose

To investigate whether the volume doubling time is a preoperative predictor of lymph node metastasis of clinical stage IA non-small cell lung cancer (NSCLC).

Methods

The subjects of this retrospective study were 204 patients who underwent lobectomy and mediastinal lymph node dissection for clinical stage IA NSCLC. We analyzed the relationship between lymph node metastasis and clinicopathological factors, including the volume doubling time.

Results

Lymph node metastasis developed in 24 (11.8%) patients. Multivariable analysis identified consolidation diameter (Odds ratio = 1.407; 95% confidence interval, 1.007–1.966, p = 0.046) and the solid-part tumor volume doubling time (Odds ratio = 0.982; 95% confidence interval, 0.973–0.991, p < 0.001) as independent predictors of lymph node metastasis. The combination of a larger consolidation diameter (> 1.9 cm) and a shorter solid-part tumor volume doubling time (< 132 days) had sensitivity, specificity, and accuracy of 79.2%, 94.4%, and 92.6%, respectively.

Conclusions

The consolidation diameter and solid-part tumor volume doubling time can be useful preoperative predictors of lymph node metastasis of clinical stage IA NSCLC.

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Acknowledgements

We thank Mr. Masataka Taguri, Ph.D., of the Department of Data Science, Yokohama City University, School of Data Science, 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa, Japan, for assistance with the statistical analyses in this study.

Funding

We received no funding for this study.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Yamagata Prefectural Central Hospital, 1800, Ooazaaoyagi, Yamagata, Yamagata, 990-2292, Japan

    Kenta Nakahashi, Satoshi Shiono, Marina Nakatsuka & Makoto Endo

Authors
  1. Kenta Nakahashi
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  2. Satoshi Shiono
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  3. Marina Nakatsuka
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  4. Makoto Endo
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Correspondence to Satoshi Shiono.

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Fig. S1 Distribution of time from the date when computed tomography detected lung nodules to the date of preoperative computed tomography and (a) the whole-tumor volume doubling time or (b) the solid-part tumor volume doubling time

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Nakahashi, K., Shiono, S., Nakatsuka, M. et al. Prediction of lymph node metastasis of clinical stage IA non-small cell lung cancer based on the tumor volume doubling time. Surg Today 52, 1063–1071 (2022). https://doi.org/10.1007/s00595-022-02450-6

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  • DOI: https://doi.org/10.1007/s00595-022-02450-6

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