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Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine

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Abstract

Purpose

At present, ≥ 20% of patients experience clinically relevant postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).

Methods

We developed a new bioabsorbable pancreatic clip (BioPaC) made of polycaprolactone that does not crush the pancreatic parenchyma during occlusion of the pancreatic stump. We confirmed the efficacy of this BioPac in a porcine DP model and compared it to a linear stapling device (Reinforce®).

Results

Pigs were killed at 1 month after DP. In the BioPaC group, all swine (n = 3) survived well without POPF. In the Reinforce® group (n = 2), one pig died early at postoperative day 7 with Grade C POPF (amylase 43 700 U/l), and the other survived until 1 month at scarification with biochemical leakage of POPF (amylase 3 725 U/l). Pathologically, the main pancreatic duct and pancreatic parenchyma were well closed by BioPaC.

Conclusion

The newly developed BioPaC is effective in a porcine DP model.

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Acknowledgements

We have applied for a PCT patent concerning this work as follows: Baba, H., Yamashita, H., and Ijima, H. inventors; Kumamoto University, and Kyushu University, assignees. Organ Resection Stump Fixing Clip. PCT Application No. PCT/JP2020/011641, filed March 17, 2020. This research was supported by AMED under Grant Number JP18lm0203009 and JP20ml0203112, and Grants-in-Aid for Scientific Research (KAKENHI) under Grant Number 21K19534. This work was supported by the Center for Clinical and Translational Research of Kyushu University and the Kumamoto Innovative Department Organization.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan

    Yo-ichi Yamashita, Takanobu Yamao, Yosuke Nakao, Tatsunori Miyata & Hideo Baba

  2. Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan

    Yasuhiro Ikegami, Soichiro Yamane, Taiga Ito, Taku Furukawa, Jaeyong Cho, Fanqi Wu & Hiroyuki Ijima

  3. Kumamoto Innovative Department Organization, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan

    Yasumitsu Fujie

  4. Center for Clinical and Translational Research, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Mitsuru Arima

  5. Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga, 849-8501, Japan

    Shinichi Aishima

Authors
  1. Yo-ichi Yamashita
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  2. Takanobu Yamao
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  3. Yosuke Nakao
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  4. Tatsunori Miyata
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  5. Yasuhiro Ikegami
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  6. Soichiro Yamane
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  7. Taiga Ito
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  8. Taku Furukawa
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  9. Jaeyong Cho
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  10. Fanqi Wu
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  11. Yasumitsu Fujie
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  12. Mitsuru Arima
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  13. Shinichi Aishima
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  14. Hiroyuki Ijima
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  15. Hideo Baba
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Contributions

Conception and design; Yamashita, Ijima, and Baba. Analysis and interpretation; Yamashita, Ijima, and Aishima. Data collection: Yamashita, Yamao, Nakao, Miyata, Ikegami, Yamane, Ito, Furukawa, Cho, Wu, and Ijima. Writing article; Yamashita and Ijima. Critical revision of the article: Baba. Obtaining funding: Yamashita, Arima, Fujie, and Baba.

Corresponding authors

Correspondence to Yo-ichi Yamashita or Hideo Baba.

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Conflict of interest

We have applied for a PCT patent concerning this work as follows: Baba, H., Yamashita, H., and Ijima, H. inventors; Kumamoto University, and Kyushu University, assignees. Organ Resection Stump Fixing Clip. PCT Application No. PCT/JP2020/011641, filed March 17, 2020.

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Registry and the registration no. of the study/trial

N/A.

Animal study

This study was performed in the Center for Animal Resources and Development of Kumamoto University, and the Kumamoto University Institutional Animal Care and Use Committee approved the animal protocol (A2020-072).

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Yamashita, Yi., Yamao, T., Nakao, Y. et al. Efficacy of a newly developed bioabsorbable pancreatic clip for distal pancreatectomy in swine. Surg Today 52, 1109–1114 (2022). https://doi.org/10.1007/s00595-021-02435-x

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  • DOI: https://doi.org/10.1007/s00595-021-02435-x

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