Skip to main content

Advertisement

SpringerLink
Log in

Feasibility of hepatic resection for liver metastasis of head-and-neck carcinoma or esophageal carcinoma: a multi-center experience

  • Original Article
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Purpose

Patients with liver metastasis of head-and-neck carcinoma and esophageal carcinoma are generally not treated with hepatic resection, but there are no established standard treatment methods. We report 11 cases of hepatic resection for liver metastasis of head-and-neck carcinoma or esophageal carcinoma performed at 5 Japanese institutions.

Methods

The subjects of this retrospective analysis were 11 patients who underwent hepatic resection for metastatic liver tumors, originating from head-and-neck carcinoma in 5 and from esophageal cancer in 6, between January, 2010 and March, 2020

Results

There were nine men and two women (median age, 64 years; range 40–72 years). The primary disease was esophageal carcinoma in six patients and pharyngeal carcinoma in five patients. All cancers were squamous cell carcinoma. The time from the initial treatment to the diagnosis of liver metastasis was 15.3 months and the 1-year and 3-year overall survival rates after hepatic resection were 72% and 32%, respectively. The overall and disease-free survival rates after hepatic resection were significantly higher for patients who underwent hepatic resection more than 12 months after the initial treatment than for those who underwent hepatic resection within 12 months after the initial treatment (p = 0.0172 and p = 0.0120, respectively).

Conclusions

Liver resection may prolong the survival of patients with liver metastases controlled for more than 12 months after the initial treatment of head and neck or esophageal carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Rees M, Tekkis PP, Welsh FKS, O’Rourke T, John TG. Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann Surg. 2008;247:125–35.

    Article  Google Scholar 

  2. Chua MLK, Wee JTS, Hui EP, Chan ATC. Nasopharyngeal carcinoma. Lancet. 2016;387:1012–24.

    Article  Google Scholar 

  3. Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y, Muto M. Recent advances from basic and clinical studies of esophageal squamous cell carcinoma. Gastroenterology. 2015;149:1700–15.

    Article  Google Scholar 

  4. Huang J, Li Q, Zheng Y, Shen J, Li B, Zou R, et al. Partial hepatectomy for liver metastases from nasopharyngeal carcinoma: a comparative study and review of the literature. BMC Cancer. 2014;14:818.

    Article  Google Scholar 

  5. Huddy JR, Thomas RL, Worthington TR, Karanjia ND. Liver metastases from esophageal carcinoma: is there a role for surgical resection? Dis Esophagus. 2015;28:483–7.

    Article  CAS  Google Scholar 

  6. Ichida H, Imamura H, Yoshimoto J, Sugo H, Kajiyama Y, Tsurumaru M, et al. Pattern of postoperative recurrence and hepatic and/or pulmonary resection for liver and/or lung metastases from esophageal carcinoma. World J Surg. 2013;37:398–407.

    Article  Google Scholar 

  7. Tseng RH, Wu HC, Chung CH, Lai GM, Lin JT. Elimination liver metastasis of nasopharyngeal carcinoma might improve overall survival. J Cancer Res Pract. 2017;4:63–5.

    Article  Google Scholar 

  8. Pawlik TM, Gleisner AL, Bauer TW, Adams RB, Reddy SK, Clary BM, et al. Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysis. Ann Surg Oncol. 2007;14:2807–16.

    Article  Google Scholar 

  9. Hayashi H, Takamura H, Nakanuma S, Kinoshita J, Makino I, Nakamura K, et al. Aggressive surgical management for metastatic liver tumors from squamous cell carcinomas: report of three cases. Int Surg. 2015;100:1271–5.

    Article  Google Scholar 

Download references

Funding

No funding was received for this study.

Author information

Authors and Affiliations

  1. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Takeshi Kurihara, Shinji Itoh, Yasue Kimura, Eiji Oki, Tomoharu Yoshizumi & Masaki Mori

  2. Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Mioko Matuo & Ryuji Yasumatsu

  3. Department of Hepatobiliary-Pancreatic Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan

    Keishi Sugimachi

  4. Cancer Research Division, Department of Gastrointestinal Surgery and Clinical Research Institute, National Kyushu Medical Center, Fukuoka, Japan

    Masaru Morita

  5. Department of Gastroenterological Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan

    Tetsuya Kusumoto

  6. Department of Surgery, Oita Red Cross Hospital, Oita, Japan

    Kengo Fukuzawa

  7. Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan

    Naoya Yoshida & Hideo Baba

Authors
  1. Takeshi Kurihara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shinji Itoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yasue Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Eiji Oki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tomoharu Yoshizumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mioko Matuo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ryuji Yasumatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Keishi Sugimachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Masaru Morita
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Tetsuya Kusumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Kengo Fukuzawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Naoya Yoshida
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Hideo Baba
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Masaki Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

TK and SI designed the study. TK, SI, YK, EO, TY, MM, RY, KS, MM, TK, KF, NY, and HB performed the study. TK, SI, and TY collected and analyzed the data. TK wrote the paper. Masaki Mori approved the final manuscript.

Corresponding author

Correspondence to Shinji Itoh.

Ethics declarations

Conflict of interest statement

We have no conflicts of interest to declare.

Ethical statements

The study protocol was approved by the institutional review board (Approved number 2019-234).

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kurihara, T., Itoh, S., Kimura, Y. et al. Feasibility of hepatic resection for liver metastasis of head-and-neck carcinoma or esophageal carcinoma: a multi-center experience. Surg Today 51, 1932–1937 (2021). https://doi.org/10.1007/s00595-021-02305-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-021-02305-6

Keywords

Search

Navigation