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Anatomical resection is useful for the treatment of primary solitary hepatocellular carcinoma with predicted microscopic vessel invasion and/or intrahepatic metastasis

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Abstract

Purpose

The aim of this study was to evaluate anatomical resection (AR) versus non-AR for primary solitary hepatocellular carcinoma (HCC) with predicted microscopic vessel invasion (MVI) and/or microscopic intrahepatic metastasis (MIM).

Methods

This retrospective study included 358 patients who underwent hepatectomy and had no evidence of MVI and/or MIM on preoperative imaging. The predictors of MVI and/or MIM were identified. The AR group (n = 222) and the non-AR group (n = 136) were classified by number of risk factor, and the survival rates were compared.

Results

Microscopic vessel invasion and/or MIM were identified in 81 (22.6%) patients. A multivariate analysis showed that high des-gamma-carboxy prothrombin concentration [odds ratio (OR) 3.35], large tumor size (OR 3.16), and high aspartate aminotransferase concentration (OR 2.13) were significant predictors. The 5-year overall survival (OS) in the patients with zero, one, two, and three risk factors were 97.4%, 73.5%, 71.5%, and 65.5%, respectively. The OS of AR is superior to that of non-AR only in patients with one or two risk factors.

Conclusion

The present findings suggest that AR should be performed for patients with one or two risk factors, and that AR may prevent recurrence, as these patients are at risk of having MVI and/or MIM.

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Acknowledgments

We thank Kelly Zammit, BVSc, from Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this manuscript.

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Correspondence to Yukiyasu Okamura.

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All authors have no conflict of interest regarding the current study.

Ethical approval

This study confirmed to the ethical guidelines of the Declaration of Helsinki (2013 revision) and was retrospective in nature, and we obtained approval from the Institutional Review Board of Shizuoka Cancer Center for the exception of patient consent (Approval Number: J2019-60).

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Okamura, Y., Sugiura, T., Ito, T. et al. Anatomical resection is useful for the treatment of primary solitary hepatocellular carcinoma with predicted microscopic vessel invasion and/or intrahepatic metastasis. Surg Today 51, 1429–1439 (2021). https://doi.org/10.1007/s00595-021-02237-1

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  • DOI: https://doi.org/10.1007/s00595-021-02237-1

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