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Prognostic significance of propofol-based intravenous anesthesia in early-stage lung cancer surgery

Surgery Today volume 51, pages 1300–1308 (2021)Cite this article

Abstract

Purpose

The purpose of this study was to assess whether the anesthetic type is associated with the prognosis of pathological stage I non-small cell lung cancer (NSCLC).

Methods

Clinicopathological data from 431 consecutive patients who underwent lobectomy for NSCLC between 2010 and 2016 were collected. Patients were classified into groups according to the type of anesthesia: propofol-based total intravenous anesthesia (TIVA) or inhalation anesthesia (INHA). We investigated the prognostic differences between these two groups.

Results

A total of 72 patients in the TIVA group and 158 patients in the INHA group were eligible for the analysis. Recurrence was observed in 4 (5.6%) patients in the TIVA group and 19 (12.0%) patients in the INHA group (P = 0.159), and all-cause death occurred in 4 (5.6%) patients in the TIVA group and 24 (15.2%) patients in the INHA group (P = 0.049). The 5-year recurrence-free survival (RFS) and overall survival rates of the TIVA/INHA groups were 91.7%/77.4% and 94.4%/83.5%, respectively. TIVA was associated with a significantly better prognosis. A multivariable analysis of factors associated with RFS revealed that the type of anesthesia as a significant prognostic factor (P = 0.047).

Conclusion

Propofol-based TIVA was associated with a better prognosis in comparison to INHA in patients with surgically resected pathological stage I NSCLC.

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Funding

There are no funding sources to be disclosed in relation to this study.

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Affiliations

  1. Department of Thoracic Surgery, Yamagata Prefectural Central Hospital, 1800, Ooazaaoyagi, Yamagata, 990-2292, Japan

    Kazuki Hayasaka, Satoshi Shiono & Makoto Endoh

  2. Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Kazuki Hayasaka & Yoshinori Okada

  3. Teikyo University Graduate School of Public Health, Tokyo, Japan

    Satoshi Miyata

  4. Department of Anesthesiology, Yamagata Prefectural Central Hospital, Yamagata, Japan

    Seiji Takaoka

Authors
  1. Kazuki Hayasaka
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  2. Satoshi Shiono
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  3. Satoshi Miyata
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  4. Seiji Takaoka
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  5. Makoto Endoh
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  6. Yoshinori Okada
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Corresponding author

Correspondence to Satoshi Shiono.

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The authors declare no conflicts of interest in association with the present study.

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Hayasaka, K., Shiono, S., Miyata, S. et al. Prognostic significance of propofol-based intravenous anesthesia in early-stage lung cancer surgery. Surg Today 51, 1300–1308 (2021). https://doi.org/10.1007/s00595-020-02216-y

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  • DOI: https://doi.org/10.1007/s00595-020-02216-y

Keywords

  • Lung cancer
  • Surgery
  • Prognosis
  • Propofol
  • Total intravenous anesthesia