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Impact of an older donor pancreas on the outcome of pancreas transplantation: single-center experience of the expansion of donor criteria

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Abstract

Purpose

The impact of using an older donor pancreas on the clinical outcomes of pancreas transplantation (PTx) is unknown. We investigated this by comparing the outcomes of PTx using older and younger donors in a single Japanese center, to expand the donor criteria.

Methods

The subjects were 54 patients who received PTx from deceased donors in our institution. Posttransplant outcomes were analyzed based on donor age, with older donors defined as those aged ≥ 60 years.

Results

The donors included six older (11.1%; aged 64 ± 4 years) and 48 younger donors (88.9%; aged 43 ± 12 years). There was no significant difference in the donor age between the recipients with vs. those without postoperative complications or between those with vs. those without early pancreas graft loss. Long-term outcomes, including overall, pancreas graft, and kidney graft survival after PTx, did not differ significantly between the older and younger donor groups. Graft age, defined as the age of the donor at the time of procurement plus the graft survival period, was not associated with graft loss.

Conclusion

Our results suggest that post-transplant outcomes of PTx using pancreas from older donors aged ≥ 60 years are comparable to those using pancreas from younger donors, and support expansion of the donor pool for transplantation therapy for type 1 diabetes mellitus.

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Author notes

  1. Yoshito Tomimaru and Koichi Kawamoto contributed equally to this work.

Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka E-2, Suita, Osaka, 565-0871, Japan

    Yoshito Tomimaru, Koichi Kawamoto, Shogo Kobayashi, Toshinori Ito, Yoshifumi Iwagami, Daisaku Yamada, Hirofumi Akita, Takehiro Noda, Kunihito Gotoh, Yuichiro Doki & Hidetoshi Eguchi

  2. Kinki Regional Bureau of Health and Welfare, Ministry of Health, Labour and Welfare, Osaka, Japan

    Koichi Kawamoto

  3. Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan

    Toshinori Ito

Authors
  1. Yoshito Tomimaru
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  2. Koichi Kawamoto
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  3. Shogo Kobayashi
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  4. Toshinori Ito
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  5. Yoshifumi Iwagami
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  6. Daisaku Yamada
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  8. Takehiro Noda
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  9. Kunihito Gotoh
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Corresponding author

Correspondence to Shogo Kobayashi.

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Yoshito Tomimaru and the co-authors have no conflicts of interest.

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Tomimaru, Y., Kawamoto, K., Kobayashi, S. et al. Impact of an older donor pancreas on the outcome of pancreas transplantation: single-center experience of the expansion of donor criteria. Surg Today 51, 232–241 (2021). https://doi.org/10.1007/s00595-020-02099-z

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  • DOI: https://doi.org/10.1007/s00595-020-02099-z

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