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Evaluation of negative-pressure wound therapy for surgical site infections after ileostomy closure in colorectal cancer patients: a prospective multicenter study

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Abstract

Purpose

Surgical site infection (SSI) occurs at a high rate after ileostomy closure. The effect of preventive negative-pressure wound therapy (NPWT) on SSI development in closed wounds remains controversial. We conducted a prospective multicenter study to evaluate the usefulness of preventive NPWT for SSI after ileostomy closure.

Methods

From January 2018 to November 2018, 50 patients who underwent closure of ileostomy created after surgery for colorectal cancer participated in this study. An NPWT device was applied to each wound immediately after surgery and then treatment was continued for 3 days. The primary endpoint was 30-day SSI, and the secondary endpoints were the incidence of seroma, hematoma, and adverse events related to NPWT.

Results

No patients developed SSI, seroma, or hematoma. Adverse events that may have been causally linked with NPWT were contact dermatitis in two patients and wound pain in one patient, and there were no cases of discontinuation or decompression of NPWT.

Conclusion

The use of NPWT following ileostomy closure may be useful for reducing the development of SSI in colorectal cancer patients. This is a prospective multicenter pilot study and we are planning a comparative study based on these successful results.

Trail registration

Registration number: UMIN000032053 (https://www.umin.ac.jp/).

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Acknowledgements

We are grateful to Drs. M. Kimura (Saiseikai Otaru Hospital), J. Kimura (Hokkaido Ohno Memoriarl Hospital), M Nishimori (Sapporo Dohto Hospital), H Ohshima (Sapporo Teishinkai Hospital), and S. Son (Saiseikai Otaru Hospital) for their assistance in this study.

Funding

This research was carried out using research funds from the Sapporo Medical University. There was no financial support from any companies.

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Author notes

  1. Ichiro Takemasa equal first contributor.

Authors and Affiliations

  1. Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, S1, W16, Chuo-ku, Sapporo, 060-8543, Japan

    Koichi Okuya, Ichiro Takemasa, Kenji Okita, Toshihiko Nishidate, Emi Akizuki, Atsushi Hamabe & Masayuki Ishii

  2. Department of Surgery, JR Sapporo Hospital, N3, E1, Chuo-ku, Sapporo, 060-0033, Japan

    Tetsuhiro Tsuruma & Tomomi Ueki

  3. Department of Surgery, Otaru Ekisaikai Hospital, 1-4-1 Inaho, Otaru, 047-0032, Japan

    Ai Noda, Tomomi Ueki & Mitsuhiro Mukaiya

  4. Department of Surgery, Muroran City General Hospital, 3-8-1, Yamate-cho, Muroran, 051-8512, Japan

    Kenichi Sasaki & Keita Saito

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  1. Koichi Okuya
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Correspondence to Ichiro Takemasa.

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Okuya, K., Takemasa, I., Tsuruma, T. et al. Evaluation of negative-pressure wound therapy for surgical site infections after ileostomy closure in colorectal cancer patients: a prospective multicenter study. Surg Today 50, 1687–1693 (2020). https://doi.org/10.1007/s00595-020-02068-6

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  • DOI: https://doi.org/10.1007/s00595-020-02068-6

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