Surgery Today

, Volume 48, Issue 10, pp 944–950 | Cite as

Single lung transplantation for lymphangioleiomyomatosis: a single-center experience in Japan

  • Hisashi Oishi
  • Tatsuaki Watanabe
  • Yasushi Matsuda
  • Masafumi Noda
  • Yutaka Ejima
  • Yoshikatsu Saiki
  • Kuniaki Seyama
  • Takashi Kondo
  • Yoshinori Okada
Original Article



Lung transplantation is accepted as an effective modality for patients with end-stage pulmonary lymphangioleiomyomatosis (LAM). Generally, bilateral lung transplantation is preferred to single lung transplantation (SLT) for LAM because of native lung-related complications, such as pneumothorax and chylothorax. It remains controversial whether SLT is a suitable surgical option for LAM. The objective of this study was to evaluate the morbidity, mortality and outcome after SLT for LAM in a lung transplant center in Japan.


We reviewed the records of 29 patients who underwent SLT for LAM in our hospital between March, 2000 and November, 2017. The data collected included the pre-transplant demographics of recipients, surgical characteristics, complications, morbidity, mortality and survival after SLT for LAM.


The most common complication after SLT for LAM was contralateral pneumothorax (n = 7; 24.1%). Six of these recipients were treated successfully with chest-tube placement and none required surgery for the pneumothorax. The second-most common complication was chylous pleural effusion (n = 6; 20.7%) and these recipients were all successfully treated by pleurodesis. The 5-year survival rate after SLT for LAM was 79.5%.


LAM-related complications after SLT for this disease can be managed. SLT is a treatment option and may improve access to lung transplantation for patients with end-stage LAM.


Lymphangioleiomyomatosis Single lung transplantation Pneumothorax Chylous pleural effusion 



We thank Brent Bell for assistance with editing this manuscript.

Compliance with ethical standards

Conflict of interest

Hisashi Oishi and his co-authors have no conflicts of interest.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018
corrected publication June 2018

Authors and Affiliations

  1. 1.Department of Thoracic Surgery, Institute of Development, Aging and CancerTohoku UniversityAobakuJapan
  2. 2.Department of AnesthesiologyTohoku University HospitalSendaiJapan
  3. 3.Department of Cardiovascular SurgeryTohoku University Graduate School of MedicineSendaiJapan
  4. 4.Division of Respiratory Medicine, Faculty of Medicine and Graduate School of MedicineJuntendo UniversityTokyoJapan
  5. 5.Department of Thoracic SurgeryTohoku Medical and Pharmaceutical UniversitySendaiJapan

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