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Surgery Today

, Volume 48, Issue 5, pp 517–524 | Cite as

The preoperative HbA1c level is an independent prognostic factor for the postoperative survival after resection of non-small cell lung cancer in elderly patients

  • Makoto Motoishi
  • Satoru Sawai
  • Tetsuo Hori
  • Naoki Yamashita
Original Article
  • 188 Downloads

Abstract

Purpose

The aim of this study was to investigate the influence of a history of diabetes mellitus (DM) and the glycated hemoglobin (HbA1c) level on the survival in patients who underwent complete resection for non-small cell lung cancer (NSCLC).

Methods

Of the patients who underwent complete resection for NSCLC between 2007 and 2015, 468 were classified into DM (who were currently taking medication for DM) and no DM groups as well as into high HbA1c (≥ 6.5) and normal HbA1c (< 6.5) groups.

Results

The overall survival (OS) did not differ significantly between either pair of groups. Among the elderly patients, the OS did not differ significantly between the DM and no DM groups, but was significantly higher in the normal-HbA1c group than in the high-HbA1c group (5-year survival rate: 84.7 versus 37.2%, respectively, p < 0.01). In the elderly patients, non-adenocarcinoma histology, advanced stage, a high Charlson comorbidity index, and a high preoperative HbA1c level were found to be independent risk factors for the OS.

Conclusion

We revealed that a high preoperative HbA1c level was associated with a poor OS in elderly patients who underwent complete resection for NSCLC. This suggests that it is necessary to achieve diabetic control prior to complete resection in NSCLC patients.

Keywords

Diabetes mellitus (DM) Glycated hemoglobin (HbA1c) Non-small cell lung cancer (NSCLC) Operation 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interests associated with this study.

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Copyright information

© Springer Japan KK, part of Springer Nature 2017

Authors and Affiliations

  • Makoto Motoishi
    • 1
  • Satoru Sawai
    • 2
  • Tetsuo Hori
    • 1
  • Naoki Yamashita
    • 1
  1. 1.Department of Thoracic SurgeryMitsubishikyoto HospitalKyotoJapan
  2. 2.Department of Thoracic SurgeryNational Hospital Organization Kyoto Medical CenterKyotoJapan

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