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Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery: a multi-center analysis

Surgery Today volume 48, pages 73–79 (2018)Cite this article

Abstract

Purpose

The influence of allogenic blood transfusion on the postoperative outcomes of hepatocellular carcinoma (HCC) surgery remains controversial. This study aims to clarify the clinical impacts of perioperative allogenic blood transfusion on liver resection outcome in HCC patients.

Methods

We analyzed data collected over 5 years for 642 patients who underwent hepatectomy for HCC at one of the five university hospitals. We investigated the impact of allogenic blood transfusion on postoperative outcome after surgery in all patients and in 74 matched pairs, using a propensity score.

Results

Of the 642 patients, 198 (30.8%) received perioperative allogenic blood transfusion (AT group) and 444 (69.2%) did not (non-AT group). Overall survival was lower in the AT group than in the non-AT group in univariate (P < 0.001) and multivariate analyses (risk ratio 1.521, P = 0.011). After matching the different distributions using propensity scores, perioperative blood transfusion was found to be a poor prognostic factor for HCC patients.

Conclusions

In this multi-center study, perioperative blood transfusion was an independent factor for poor prognosis after curative surgery for primary HCC in the patient group and in pairs matched by propensity scores.

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Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan

    Hiroshi Wada, Hidetoshi Eguchi, Hiroaki Nagano, Yuichiro Doki & Masaki Mori

  2. Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Osaka, 545-8585, Japan

    Shoji Kubo, Shigekazu Takemura & Shogo Tanaka

  3. Department of Surgery, Kinki University School of Medicine, Sayama, Osaka, 589-8511, Japan

    Takuya Nakai & Yasuyuki Nakata

  4. Department of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka, 573-1191, Japan

    Masaki Kaibori, Kosuke Matsui, Morihiko Ishizaki & Masanori Kon

  5. Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Osaka, 569-8686, Japan

    Michihiro Hayashi, Fumitoshi Hirokawa, Koji Komeda & Kazuhisa Uchiyama

Authors
  1. Hiroshi Wada
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  2. Hidetoshi Eguchi
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  3. Hiroaki Nagano
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  11. Kosuke Matsui
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  15. Kazuhisa Uchiyama
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  16. Masanori Kon
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  17. Yuichiro Doki
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  18. Masaki Mori
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Corresponding author

Correspondence to Hidetoshi Eguchi.

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Hiroshi Wada and his co-authors have no conflicts of interest to declare.

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Wada, H., Eguchi, H., Nagano, H. et al. Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery: a multi-center analysis. Surg Today 48, 73–79 (2018). https://doi.org/10.1007/s00595-017-1553-3

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  • DOI: https://doi.org/10.1007/s00595-017-1553-3

Keywords

  • Hepatectomy
  • Prognosis
  • Transfusion
  • Hepatocellular carcinoma