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Complications in hepatic arterial infusion chemotherapy: retrospective comparison of catheter tip placement in the right/left hepatic artery vs. the gastroduodenal artery

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Abstract

Purpose

To compare the complication rates associated with hepatic arterial infusion chemotherapy (HAIC) for unresectable hepatocellular carcinoma (HCC) using two different catheter tip locations, the right/left hepatic artery (group 1) and the gastroduodenal artery (group 2).

Methods

Between April 2001 and March 2015, 88 patients (group 1, n = 36; group 2, n = 52) with unresectable HCC, underwent HAIC via a transfemorally placed infusion catheter. The incidence of complications related to catheter placement (including hepatic arterial occlusion, catheter dislocation, non-target embolization and port-catheter system infection) as well as catheter patency and patient survival were evaluated.

Results

The technical success rate was 100%. The overall complication rate was 17% (15/88 patients). The specific complications were as follows: hepatic artery occlusion, n = 1 (group 2, n = 1), gastroduodenal ulcer, n = 6 (group 1, n = 2; group 2, n = 4); catheter dislocation, n = 1 (group 2, n = 1); port-catheter system infection, n = 3 (group 2, n = 3); and bleeding at the puncture site, n = 4 (group 1, n = 1; group 2, n = 3).

Conclusions

The complication rates in groups 1 and 2 did not differ to a statistically significant extent.

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Authors and Affiliations

  1. Department of Radiology, Kyoto University Graduate School of Medicine, 54-Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan

    Rinpei Imamine, Toshiya Shibata, Ken Shinozuka & Kaori Togashi

Authors
  1. Rinpei Imamine
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  2. Toshiya Shibata
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  3. Ken Shinozuka
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  4. Kaori Togashi
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Corresponding author

Correspondence to Toshiya Shibata.

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The authors declare no conflicts of interest in association with this study.

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Imamine, R., Shibata, T., Shinozuka, K. et al. Complications in hepatic arterial infusion chemotherapy: retrospective comparison of catheter tip placement in the right/left hepatic artery vs. the gastroduodenal artery. Surg Today 47, 851–858 (2017). https://doi.org/10.1007/s00595-016-1465-7

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  • DOI: https://doi.org/10.1007/s00595-016-1465-7

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