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Duodenal-jejunal bypass changes the composition of the gut microbiota

Surgery Today volume 47, pages 137–140 (2017)Cite this article

Abstract

This study investigated the composition of the gut microbiota in rats after duodenal-jejunal bypass (DJB) in comparison to that in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog. Six male 16-week-old OLETF rats were divided into three groups: a DJB group, a sham operation group, and a daily injection with a GLP-1 receptor agonist (liraglutide) group. The gut microbiota of the three groups was analyzed at postoperative week 8 using the PCR-clone library method targeting the 16S ribosomal RNA gene. The DJB group showed a decrease in Bacteroidia in comparison to the other two groups (DJB, 3.9 %/2.8 %; sham, 10.8 %/11.6 %; liraglutide, 33.2 %/14.1 %). In addition, DJB markedly increased the ratio of Gammaproteobacteria (DJB, 10.8 %/13.7 %; sham, 0.2 %/1.2 %; liraglutide, 0 %/0.1 %). DJB changes the composition of gut microbiota; these changes might be the factors that contribute to the effects of DJB.

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Fig. 1

Abbreviations

DJB:

Duodenal-jejunal bypass

GLP-1:

Glucagon-like peptide-1

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Acknowledgments

We are thankful to the staff of the Department of Surgery, Institute of Health Biosciences, University of Tokushima, for their contributions.

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Affiliations

  1. Department of Surgery, Institute of Health Biosciences, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan

    Hideya Kashihara, Mitsuo Shimada, Kozo Yoshikawa, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi & Chie Takasu

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  1. Hideya Kashihara
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  2. Mitsuo Shimada
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  3. Kozo Yoshikawa
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  4. Jun Higashijima
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  5. Toshihiro Nakao
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  6. Masaaki Nishi
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  7. Chie Takasu
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Correspondence to Hideya Kashihara.

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The authors declare no conflicts of interest in association with the present study.

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Kashihara, H., Shimada, M., Yoshikawa, K. et al. Duodenal-jejunal bypass changes the composition of the gut microbiota. Surg Today 47, 137–140 (2017). https://doi.org/10.1007/s00595-016-1373-x

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Keywords

  • Duodenal-jejunal bypass
  • Gut microbiota