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Beneficial effects of a cardiac support device on left ventricular remodeling after posterior myocardial infarction: an evaluation by echocardiography, pressure–volume curves and ventricular histology

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Abstract

Purpose

Posterior myocardial infarction (MI) can induce LV remodeling and ischemic mitral regurgitation (IMR). The protective effects of a cardiac support device (CSD) against LV remodeling and IMR after posterior MI have been poorly documented.

Methods

Posterior MI was induced by ligation of the left circumflex coronary artery in beagle dogs. After 7 days, the dogs were randomized to a CSD placement (CSD group, n = 8) or no treatment (CTL group, n = 8).

Results

At 3 months after MI, the LV remodeling was less marked and the LV and RV systolic functions were better in the CSD group than in the CTL group. Neither the RV nor LV diastolic function (min dP/dt, Tau and EDPVR) was disturbed by the CSD. IMR was consistently prevented in our canine model.

Conclusion

Early application of a CSD after posterior MI can attenuate LV remodeling without causing any deterioration of the biventricular diastolic function.

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Abbreviations

IMR:

Ischemic mitral regurgitation

CSD:

Cardiac support device

CTL:

Control

LV:

Left ventricular

RV:

Right ventricular

EF:

Ejection fraction

ESV:

End-systolic volume

EDV:

End-diastolic volume

LVDd:

Left ventricular end-diastolic dimension

LVDs:

Left ventricular end-systolic dimension

MR:

Mitral regurgitation

TR:

Tricuspid regurgitation

MI:

Myocardial infarction

ESP:

End-systolic pressure

EDP:

End-diastolic pressure

dP/dt:

Delta pressure/delta time

EDPVR:

End-diastolic pressure–volume relationship

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Acknowledgments

We are very grateful to Yoshihide Asakawa (Nihon Kohden Co., Ltd.) and Takashi Nakasaki and Minoru Iwata (Taisho Biomed Instruments Co., Ltd.) for their valuable assistance with the experiments.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Kanazawa Medical University, Daigaku 1-1, Uchinadamachi, Kahokugun, Ishikawa, Japan

    Miyako Okada, Toshiaki Akita, Fumito Mizuno, Asami Nakayama & Kouichi Morioka

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  1. Miyako Okada
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  2. Toshiaki Akita
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  3. Fumito Mizuno
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  4. Asami Nakayama
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  5. Kouichi Morioka
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Correspondence to Toshiaki Akita.

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Okada, M., Akita, T., Mizuno, F. et al. Beneficial effects of a cardiac support device on left ventricular remodeling after posterior myocardial infarction: an evaluation by echocardiography, pressure–volume curves and ventricular histology. Surg Today 46, 621–630 (2016). https://doi.org/10.1007/s00595-015-1202-7

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  • DOI: https://doi.org/10.1007/s00595-015-1202-7

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