Skip to main content

Advertisement

SpringerLink
Log in

Lymphatic vessel invasion in pathologic stage I and II non-small cell lung tumors

  • Original Article
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Purpose

Tumor node-metastasis staging is essential for predicting the prognosis of patients with non-small cell lung cancer (NSCLC); however, its accuracy remains limited. The aim of this study was to establish the significant predictors of outcome for patients with pathologic stage I or II NSCLC.

Methods

We reviewed the records of patients with pathologic stage I and II NSCLC retrospectively. After the exclusion of those who underwent sublobar resection, received neoadjuvant treatment, or died within 30 days of surgery, 271 patients treated between January, 2004 and December, 2010 were analyzed. We investigated whether lymphatic vessel invasion (LVI) grade was associated with prognosis in stage I or II NSCLC.

Results

The median age of the patients was 64 years. Of the 198 and 73 patients with pathologic stage I and stage II disease, respectively, 73 (26.9 %) had LVI. Thirteen patients had a high degree of LVI. Although LVI was not associated with overall survival (p = 0.13), a high degree of LVI was associated with poor survival (p < 0.001). Multivariate analysis revealed that diabetes mellitus (p = 0.001), tumor size (p < 0.001), LVI grade (p < 0.001), and pathologic stage II (p = 0.040) were all associated with overall survival.

Conclusions

A higher grade of LVI was predictive of a worse prognosis. Further study is required to establish the prognostic role of moderate and marked LVI in NSCLC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277–300.

    Article  PubMed  Google Scholar 

  2. Goya T, Asamura H, Yoshimura H, Kato H, Shimokata K, Tsuchiya R, Sohara Y, Miya T, Miyaoka E. Prognosis of 6644 resected non-small cell lung cancers in Japan: a Japanese lung cancer registry study. Lung Cancer. 2005;50:227–34.

    Article  PubMed  Google Scholar 

  3. Strand TE, Rostad H, Moller B, Norstein J. Survival after resection for primary lung cancer: a population based study of 3211 resected patients. Thorax. 2006;61:710–5.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Chansky K, Sculier JP, Crowley JJ, Giroux D, Van Meerbeeck J, Goldstraw P, International Staging Committee and Participating Institutions. The International Association for the Study of Lung Cancer Staging Project: prognostic factors and pathologic TNM stage in surgically managed non-small cell lung cancer. J Thorac Oncol. 2009;4:792–801.

    Article  PubMed  Google Scholar 

  5. Japanese Gastric Cancer A. Japanese classification of gastric carcinoma—3rd English edn. Gastric cancer 2011;14:101–12.

  6. Yoshino I, Yamaguchi M, Yamazaki K, Shoji F, Hamatake M, Maehara Y. Surgical outcome of an anatomical resection of clinical stage IA non-small cell lung cancer assisted with a video-thoracoscopy. Surg Today. 2010;40:719–24.

    Article  PubMed  Google Scholar 

  7. Rigau V, Molina TJ, Chaffaud C, Huchon G, Audouin J, Chevret S, et al. Blood vessel invasion in resected non small cell lung carcinomas is predictive of metastatic occurrence. Lung Cancer. 2002;38:169–76.

    Article  CAS  PubMed  Google Scholar 

  8. Gabor S, Renner H, Popper H, Anegg U, Sankin O, Matzi V, et al. Invasion of blood vessels as significant prognostic factor in radically resected T1-3N0M0 non-small-cell lung cancer. Eur J Cardiothorac Surg. 2004;25:439–42.

    Article  CAS  PubMed  Google Scholar 

  9. Tsuchiya T, Akamine S, Muraoka M, Kamohara R, Tsuji K, Urabe S, et al. Stage IA non-small cell lung cancer: vessel invasion is a poor prognostic factor and a new target of adjuvant chemotherapy. Lung Cancer. 2007;56:341–8.

    Article  PubMed  Google Scholar 

  10. Shoji F, Haro A, Yoshida T, Ito K, Morodomi Y, Yano T, et al. Prognostic significance of intratumoral blood vessel invasion in pathologic stage IA non-small cell lung cancer. Ann Thorac Surg. 2010;89:864–9.

    Article  PubMed  Google Scholar 

  11. Araki K, Adachi Y, Metsugi H, Tokushima T. Prognostic implication of lymphatic vessel invasion in stage IB (pT2aN0M0) non-small cell lung cancer. Gen Thorac Cardiovasc Surg. 2011;59:605–8.

    Article  PubMed  Google Scholar 

  12. Funai K, Sugimura H, Morita T, Shundo Y, Shimizu K, Shiiya N. Lymphatic vessel invasion is a significant prognostic indicator in stage IA lung adenocarcinoma. Ann Surg Oncol. 2011;18:2968–72.

    Article  PubMed  Google Scholar 

  13. Hanagiri T, Takenaka M, Oka S, Shigematsu Y, Nagata Y, Shimokawa H, et al. Prognostic significance of lymphovascular invasion for patients with stage I non-small cell lung cancer. Eur Surg Res. 2011;47:211–7.

    Article  CAS  PubMed  Google Scholar 

  14. Kilicgun A, Turna A, Sayar A, Solak O, Urer N, Gurses A. Very important histopathological factors in patients with resected non-small cell lung cancer: necrosis and perineural invasion. Thorac Cardiovasc Surg. 2010;58:93–7.

    Article  CAS  PubMed  Google Scholar 

  15. Yilmaz A, Duyar SS, Cakir E, Aydin E, Demiraq F, Karakaya J, et al. Clinical impact of visceral pleural, lymphovascular and perineural invasion in completely resected non-small cell lung cancer. Eur J Cardiothorac Surg. 2011;40:664–70.

    PubMed  Google Scholar 

  16. Wang J, Wang B, Zhao W, Guo Y, Chen H, Chu H, et al. Clinical significance and role of lymphatic vessel invasion as a major prognostic implication in non-small cell lung cancer: a meta-analysis. PLoS One. 2012;7:e52704.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Hashizume S, Nagayasu T, Hayashi T, Hidaka S, Tsuchiya T, Tagawa T, et al. Accuracy and prognostic impact of a vessel invasion grading system for stage IA non-small cell lung cancer. Lung Cancer. 2009;65:363–70.

    Article  PubMed  Google Scholar 

  18. Kadota K, Huang CL, Liu D, Nakashima N, Tokomise H, Ueno M, et al. The clinical significance of the tumor cell D2-40 immunoreactivity in non-small cell lung cancer. Lung Cancer. 2010;70:88–93.

    Article  PubMed  Google Scholar 

  19. Takanami I. Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer. Oncol Rep. 2006;15:437–42.

    PubMed  Google Scholar 

  20. Iwakiri S, Nagai S, Katakura H, Takenaka K, Date H, Wada H, et al. D2-40-positive lymphatic vessel density is a poor prognostic factor in squamous cell carcinoma of the lung. Ann Surg Oncol. 2009;16:1678–85.

    Article  PubMed  Google Scholar 

  21. Faoro L, Hutto JY, Salgia R, El-Zayaty SA, Ferquson MK, Cheney RT, et al. Lymphatic vessel density is not associated with lymph node metastasis in non-small cell lung carcinoma. Arch Pathol Lab Med. 2008;132:1882–8.

    PubMed  Google Scholar 

  22. Min KH, Park SJ, Lee KS, Hwang SH, Kim SR, Moon H, et al. Clinical usefulness of D2-40 in non-small cell lung cancer. Lung. 2011;189:57–63.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We are very appreciated of Dr. Kyo Young Lee and Dr. Jeana Kim in the Department of Pathology for their pathologic interpretation.

Conflict of interest

Drs. Hyun Woo Jeon, Kyung Soo Kim, Young-Du Kim, Keon Hyun Jo, Young Pil Wang, Hyung Joo Park, and Jae Kil Park have no conflicts of interest or financial ties to disclose.

Author information

Authors and Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Republic of Korea

    Hyun Woo Jeon & Young-Du Kim

  2. Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-Gu, Seoul, 137-701, Republic of Korea

    Kyung Soo Kim, Keon Hyun Jo, Hyung Joo Park, Young Pil Wang & Jae Kil Park

Authors
  1. Hyun Woo Jeon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kyung Soo Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Young-Du Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Keon Hyun Jo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hyung Joo Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Young Pil Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jae Kil Park
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jae Kil Park.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jeon, H.W., Kim, K.S., Kim, YD. et al. Lymphatic vessel invasion in pathologic stage I and II non-small cell lung tumors. Surg Today 45, 1018–1024 (2015). https://doi.org/10.1007/s00595-014-1082-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-014-1082-2

Keywords

Search

Navigation