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Comparison of the analgesic effects of cryoanalgesia vs. parecoxib for lung cancer patients after lobectomy

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Abstract

This study was designed to compare the analgesic effects of cryoanalgesia and parecoxib in lung cancer patients after lobectomy. A total of 178 lung cancer patients awaiting large-sized lobectomy were enrolled in the study. The patients were randomly divided into Group A (intercostal nerve cryoanalgesia) and Group B (parecoxib). The analgesic and adverse effects were compared between the two groups. The pain score of Group A was significantly lower than that of Group B (P < 0.05). The patients in Group A used significantly less morphine than those in Group B (P < 0.05). There were also significantly fewer complications in Group A than in Group B (P < 0.05). Cryoanalgesia of the intercostal nerves can be considered an economical, safe and simple technique for the long-term management of post-lobectomy pain.

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References

  1. Senturk M, Ozcan PE, Talu GK, Kiyan E, Camci E, Ozyalcin S, Dilege S, Pembeci K. The effects of three different analgesia techniques on long-term postthoracotomy pain. Anesth Analg. 2002;94:11–5 table of contents.

    Article  PubMed  Google Scholar 

  2. Tiippana E, Nilsson E, Kalso E. Post-thoracotomy pain after thoracic epidural analgesia: a prospective follow-up study. Acta Anaesthesiol Scand. 2003;47:433–8.

    Article  CAS  PubMed  Google Scholar 

  3. Hazelrigg SR, Cetindag IB, Fullerton J. Acute and chronic pain syndromes after thoracic surgery. Surg Clin North Am. 2002;82:849–65.

    Article  PubMed  Google Scholar 

  4. Steegers MA, Snik DM, Verhagen AF, van der Drift MA, Wilder-Smith OH. Only half of the chronic pain after thoracic surgery shows a neuropathic component. J Pain. 2008;9:955–61.

    Article  PubMed  Google Scholar 

  5. Karmakar MK, Ho AM. Postthoracotomy pain syndrome. Thorac Surg Clin. 2004;14:345–52.

    Article  PubMed  Google Scholar 

  6. Hamada H, Moriwaki K, Shiroyama K, Tanaka H, Kawamoto M, Yuge O. Myofascial pain in patients with postthoracotomy pain syndrome. Reg Anesth Pain Med. 2000;25:302–5.

    CAS  PubMed  Google Scholar 

  7. Evans PJ, Lloyd JW, Green CJ. Cryoanalgesia: the response to alterations in freeze cycle and temperature. Br J Anaesth. 1981;53:1121–7.

    Article  CAS  PubMed  Google Scholar 

  8. Moorjani N, Zhao F, Tian Y, Liang C, Kaluba J, Maiwand MO. Effects of cryoanalgesia on post-thoracotomy pain and on the structure of intercostal nerves: a human prospective randomized trial and a histological study. Eur J Cardiothorac Surg. 2001;20:502–7.

    Article  CAS  PubMed  Google Scholar 

  9. Momenzadeh S, Elyasi H, Valaie N, Radpey B, Abbasi A, Nematollahi F, Mohammadinasab H. Effect of cryoanalgesia on post-thoracotomy pain. Acta Med Iran. 2011;49:241–5.

    PubMed  Google Scholar 

  10. Sepsas E, Misthos P, Anagnostopulu M, Toparlaki O, Voyagis G, Kakaris S. The role of intercostal cryoanalgesia in post-thoracotomy analgesia. Interact CardioVasc Thorac Surg. 2013;16:814–8.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Roxburgh JC, Markland CG, Ross BA, Kerr WF. Role of cryoanalgesia in the control of pain after thoracotomy. Thorax. 1987;42:292–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Miguel R, Hubbell D. Pain management and spirometry following thoracotomy: a prospective, randomized study of four techniques. J Cardiothorac Vasc Anesth. 1993;7:529–34.

    Article  CAS  PubMed  Google Scholar 

  13. Lloyd R, Derry S, Moore RA, McQuay HJ. Intravenous or intramuscular parecoxib for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009;15(2):CD004771.

    Google Scholar 

  14. Myles PS, Power I. Clinical update: postoperative analgesia. Lancet. 2007;369:810–2.

    Article  PubMed  Google Scholar 

  15. Matsutani N, Kawamura M. Successful management of postoperative pain with pregabalin after thoracotomy. Surg Today. 2014;44:712–5.

    Article  CAS  PubMed  Google Scholar 

  16. Data on file. Clinical study 027, February 25, 2000. New York: Pfizer inc.; 2000.

  17. Parecoxib-uk medicines information. http://www.Ukmi.Nhs.Uk/newmaterial/html/docs/parecoxib.Pdf Retrieved 1 Aug 2013.

  18. Malan TP Jr, Gordon S, Hubbard R, Snabes M. The cyclooxygenase-2-specific inhibitor parecoxib sodium is as effective as 12 mg of morphine administered intramuscularly for treating pain after gynecologic laparotomy surgery. Anesth Analg. 2005;100:454–60.

    Article  CAS  PubMed  Google Scholar 

  19. Wei W, Zhao T, Li Y. Efficacy and safety of parecoxib sodium for acute postoperative pain: a meta-analysis. Exp Ther Med. 2013;6:525–31.

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Akaraviputh T, Leelouhapong C, Lohsiriwat V, Aroonpruksakul S. Efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy: a prospective, randomized study. World J Gastroenterol. 2009;15:2005–8.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Martinez V, Belbachir A, Jaber A, Cherif K, Jamal A, Ozier Y, Sessler DI, Chauvin M, Fletcher D. The influence of timing of administration on the analgesic efficacy of parecoxib in orthopedic surgery. Anesth Analg. 2007;104:1521–7 table of contents.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Bikhazi GB, Snabes MC, Bajwa ZH, Davis DJ, LeComte D, Traylor L, Hubbard RC. A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy. Am J Obstet Gynecol. 2004;191:1183–91.

    Article  CAS  PubMed  Google Scholar 

  23. Tang J, Li S, White PF, Chen X, Wender RH, Quon R, Sloninsky A, Naruse R, Kariger R, Webb T, Norel E. Effect of parecoxib, a novel intravenous cyclooxygenase type-2 inhibitor, on the postoperative opioid requirement and quality of pain control. Anesthesiology. 2002;96:1305–9.

    Article  CAS  PubMed  Google Scholar 

  24. Malan TP Jr, Marsh G, Hakki SI, Grossman E, Traylor L, Hubbard RC. Parecoxib sodium, a parenteral cyclooxygenase 2 selective inhibitor, improves morphine analgesia and is opioid-sparing following total hip arthroplasty. Anesthesiology. 2003;98:950–6.

    Article  CAS  PubMed  Google Scholar 

  25. Schulz KF, Altman DG, Moher D. Consort 2010 statement: updated guidelines for reporting parallel group randomized trials. Open Med. 2010;4:e60–8.

    PubMed  PubMed Central  Google Scholar 

  26. Boonstra AM, Schiphorst Preuper HR, Reneman MF, Posthumus JB, Stewart RE. Reliability and validity of the visual analogue scale for disability in patients with chronic musculoskeletal pain. Int J Rehabil Res. 2008;31:165–9.

    Article  PubMed  Google Scholar 

  27. Lu Q, Han Y, Cao W, Lei J, Wan Y, Zhao F, Huang L, Li X. Comparison of non-divided intercostal muscle flap and intercostal nerve cryoanalgesia treatments for post-oesophagectomy neuropathic pain control. Eur J Cardiothorac Surg. 2013;43:e64–70.

    Article  PubMed  Google Scholar 

  28. Ding X, Jin S, Niu X, Ren H, Fu S, Li Q. A comparison of the analgesia efficacy and side effects of paravertebral compared with epidural blockade for thoracotomy: an updated meta-analysis. PLoS One. 2014;9:e96233.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Orr IA, Keenan DJ, Dundee JW. Improved pain relief after thoracotomy: use of cryoprobe and morphine infusion. Br Med J (Clin Res Ed). 1981;283:945–8.

    Article  CAS  Google Scholar 

  30. Pastor J, Morales P, Cases E, Cordero P, Piqueras A, Galan G, Paris F. Evaluation of intercostal cryoanalgesia versus conventional analgesia in postthoracotomy pain. Respiration. 1996;63:241–5.

    Article  CAS  PubMed  Google Scholar 

  31. Ju H, Feng Y, Yang BX, Wang J. Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control. Eur J Pain. 2008;12:378–84.

    Article  PubMed  Google Scholar 

  32. Joucken K, Michel L, Schoevaerdts JC, Mayne A, Randour P. Cryoanalgesia for post-thoracotomy pain relief. Acta Anaesthesiol Belg. 1987;38:179–83.

    CAS  PubMed  Google Scholar 

  33. Katz J, Nelson W, Forest R, Bruce DL. Cryoanalgesia for post-thoracotomy pain. Lancet. 1980;1:512–3.

    Article  CAS  PubMed  Google Scholar 

  34. Muller LC, Salzer GM, Ransmayr G, Neiss A. Intraoperative cryoanalgesia for postthoracotomy pain relief. Ann Thorac Surg. 1989;48:15–8.

    Article  CAS  PubMed  Google Scholar 

  35. Brichon PY, Pison C, Chaffanjon P, Fayot P, Buchberger M, Neron L, Bocca A, Verdier J, Sarrazin R. Comparison of epidural analgesia and cryoanalgesia in thoracic surgery. Eur J Cardiothorac Surg. 1994;8:482–6.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was funded by grants from the Projects in the National Science & Technology Pillar Program during the Eleventh Five-year Plan Period (No. 2006BAI02A01) provided to Yin Li, and the Jiangsu Health International Exchange Supporting Program provided to Xiao-Dong Li.

Conflict of interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Henan Cancer Hospital (The Affiliated Cancer Hospital of Zhengzhou University), 127 Dongming Rd, Zhengzhou, 450008, Henan Province, People’s Republic of China

    Yu-Feng Ba, Shan-Hong He & Yin Li

  2. Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China

    Xiao-Dong Li

  3. Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Xiaofei Zhang

  4. Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China

    Zhong-Hua Ning

  5. Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, USA

    Hanze Zhang

  6. Department of Scientific Research and Foreign Affairs, Henan Cancer Hospital (The Affiliated Cancer Hospital of Zhengzhou University), Zhengzhou, China

    Yi-Ning Liu

  7. Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Yu Zhu

  8. Department of Anesthesiology, Henan Cancer Hospital (The Affiliated Cancer Hospital of Zhengzhou University), Zhengzhou, China

    Chang-Sheng Li

  9. Department of General Surgery, No. 153 Hospital of Liberation Army, Zhengzhou, China

    Quan-Hui Wang

Authors
  1. Yu-Feng Ba
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  2. Xiao-Dong Li
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  4. Zhong-Hua Ning
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  5. Hanze Zhang
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  6. Yi-Ning Liu
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  7. Shan-Hong He
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  8. Yu Zhu
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  9. Chang-Sheng Li
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  10. Quan-Hui Wang
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  11. Yin Li
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Corresponding author

Correspondence to Yin Li.

Additional information

Y.-F. Ba, X.-D. Li and X. Zhang have contributed equally to this work.

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Ba, YF., Li, XD., Zhang, X. et al. Comparison of the analgesic effects of cryoanalgesia vs. parecoxib for lung cancer patients after lobectomy. Surg Today 45, 1250–1254 (2015). https://doi.org/10.1007/s00595-014-1043-9

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  • DOI: https://doi.org/10.1007/s00595-014-1043-9

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