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Proposal of a new prognostic staging system for pulmonary metastases from colorectal cancer

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Abstract

Purpose

The aim of this retrospective study was to establish a new prognostic staging system for pulmonary metastases from colorectal carcinoma (CRC).

Methods

The baseline characteristics and outcomes on 352 CRC patients who underwent complete pulmonary resection were collected from 19 institutions by the Japanese Society for Cancer of the Colon and Rectum (JSCCR) Study Group (group A). The clinical and pathological factors were entered into a multivariate analysis to identify independent variables that were helpful for accurately predicting the long-term prognosis after pulmonary resection. Using the selected variables in group A, we developed a new prognostic staging system (PSS). The new PSS was examined in a validation study in a series of 841 patients from 110 institutions of the JSCCR by the 78th society of the JSCCR (group B).

Results

We evaluated four variables selected in the multivariate analysis: the number of pulmonary metastases, the distribution, the disease-free interval and the lymph node metastases of primary cancer in group A. Using these four variables, we developed a new PSS. This PSS was found to significantly predict the prognosis in group B.

Conclusions

Our new PSS was useful for the selection of patients suitable for pulmonary resection.

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Acknowledgments

We thank all of the physicians at the institutions participating in the Pulmonary Metastases from Colon Cancer Project for contributing to this case series. Moreover, we thank the professors of the 110 institutes that are members of the Society of the JSCCR who responded to the questionnaires distributed at the 78th meeting of the JSCCR.

Conflict of interest

We declare no conflicts of interest in association with this study.

Author information

Authors and Affiliations

  1. Department of Surgery II, Tokyo Women’s Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Tomoichiro Hirosawa, Michio Itabashi & Shingo Kameoka

  2. Department of Thoracic Surgery, Tokyo Women’s Medical University, Tokyo, Japan

    Takamasa Ohnuki

  3. Division of Public Health, Department of Hygiene and Public Health II, Tokyo Women’s Medical University, Tokyo, Japan

    Naoto Yamaguchi

  4. Department of Surgical Oncology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

    Kenichi Sugihara

Authors
  1. Tomoichiro Hirosawa
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  2. Michio Itabashi
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  3. Takamasa Ohnuki
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  4. Naoto Yamaguchi
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  5. Kenichi Sugihara
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  6. Shingo Kameoka
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Consortia

Japanese Society for Cancer of the Colon and Rectum (JSCCR) Study Group for Pulmonary Metastases from Colorectal Cancer

Corresponding author

Correspondence to Tomoichiro Hirosawa.

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Hirosawa, T., Itabashi, M., Ohnuki, T. et al. Proposal of a new prognostic staging system for pulmonary metastases from colorectal cancer. Surg Today 45, 576–584 (2015). https://doi.org/10.1007/s00595-014-0986-1

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  • DOI: https://doi.org/10.1007/s00595-014-0986-1

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