Abstract
We report a rare case of pancreatic serous cystadenoma, which shrank remarkably from 6 to 1.5 cm in diameter, with cystic degeneration, over a period of only 3 weeks. A 29-year-old woman who presented with epigastric pain and jaundice underwent computed tomography, which showed a 6-cm monolocular cystic tumor in the pancreatic head. Endoscopic retrograde cholangiopancreatography showed stenosis and deviation of the inferior part of the extrahepatic bile duct. We performed surgery 3 weeks later for suspected mucinous cystadenoma or macroscopic serous cystadenoma of the pancreas. At laparotomy, the tumor in the pancreatic head was found to have shrunk remarkably. We excised the tumor completely by performing the Whipple procedure. Macroscopically, the mass was a 1.5-cm monolocular cyst. Microscopically, the cystic tumor was composed of a thick fibrous wall with granulation tissue and hemorrhage. Although epithelial cells were not found inside the cystic wall, numerous grossly invisible microcysts with glycogen-containing epithelial cells were seen at its periphery. Based on these findings, the tumor was diagnosed as a serous cystadenoma with cystic degeneration.
References
Kimura W, Moriya T, Hirai I, Hanada K, Abe H, Yanagisawa A, et al. Multicenter study of serous cystic neoplasm of the Japan pancreas society. Pancreas. 2012;41:380–7.
Lee SE, Kwon Y, Jang JY, Kim YH, Hwang DW, Kim MA, et al. The morphological classification of a serous cystic tumor (SCT) of the pancreas and evaluation of the preoperative diagnostic accuracy of computed tomography. Ann Surg Oncol. 2008;15:2089–95.
Perez-Ordonez B, Naseem A, Lieberman PH, Klimstra DS. Solid serous adenoma of the pancreas. The solid variant of serous cystadenoma? Am J Surg Pathol. 1996;20:1401–5.
Klöppel G, Kosmahl M. Cystic lesions and neoplasms of the pancreas. The features are becoming clearer. Pancreatology. 2001;1:648–55.
Panarelli NC, Park KJ, Hruban RH, Klimstra DS. Microcystic serous cystadenoma of the pancreas with subtotal cystic degeneration: another neoplastic mimic of pancreatic pseudocyst. Am J Surg Pathol. 2012;36:726–31.
Galanis C, Zamani A, Cameron JL, Campbell KA, Lillemoe KD, Caparrelli D, et al. Resected serous cystic neoplasms of the pancreas: a review of 158 patients with recommendations for treatment. J Gastrointest Surg. 2007;11:820–6.
Capella C, Solcia E, Kloppel G. Serous cystic neoplasms of the pancreas. Pathology and genetics of tumor of the digestive system. WHO classification of tumors. Lyon: IARC Press; 2000. p. 231–3.
Boujaoude J. Role of endoscopic ultrasound in diagnosis and therapy of pancreatic adenocarcinoma. World J Gastroenterol. 2007;13:3662–6.
De Angelis C, Repici A, Carucci P, Bruno M, Goss M, Mezzabotta L, et al. Pancreatic cancer imaging: the new role of endoscopic ultrasound. J Pancreas. 2007;8:85–97.
Khashab MA, Kim K, Lennon AM, Shin EJ, Tignor AS, Amateau SK, et al. Should we do EUS/FNA on patients with pancreatic cysts? The incremental diagnostic yield of EUS over CT/MRI for prediction of cystic neoplasms. Pancreas. 2013;42:717–21.
Kosmahl M, Pauser U, Anlauf M, Klöppel G. Pancreatic ductal adenocarcinoma with cystic features: neither rare nor uniform. Mod Pathol. 2005;18:1157–64.
Singhi AD, Chu LC, Tatsas AD, Shi C, Ellison TA, Fishman EK, et al. Cystic pancreatic neuroendocrine tumors: a clinicopathologic study. Am J Surg Pathol. 2012;36:1666–73.
Acknowledgments
This work was supported by the Kochi Organization for Medical Reformation and Renewal.
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Tatsuaki Sumiyoshi and his co-authors have no conflicts of interest to declare.
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Sumiyoshi, T., Shima, Y., Okabayashi, T. et al. Rapid shrinkage of a pancreatic serous cystadenoma with cystic degeneration: report of a case. Surg Today 45, 647–651 (2015). https://doi.org/10.1007/s00595-014-0972-7
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DOI: https://doi.org/10.1007/s00595-014-0972-7