Abstract
We report a case of bilateral lung transplantation (BLT) after preservation of the donor graft for 16 h 5 min with EP-TU, an extracellular phosphate-buffered lung preservation solution. The recipient was a 26-year-old woman with idiopathic pulmonary arterial hypertension and the graft ischemic time was prolonged significantly because of the time required to induce peripheral veno-arterial extracorporeal membrane oxygenation (V-A ECMO) under local anesthesia, and address the severe intrathoracic and pericardial adhesions from past surgery for partial anomalous pulmonary venous return, with concurrent annular plication of the tricuspid valve. After the operation, ECMO and continuous hemodiafiltration were started preemptively to protect the grafts against excessive edema. Postoperative chest X-ray showed diffuse bilateral infiltrates, which improved within a few days and she was weaned off ECMO on day 9. Successful BLT after a graft ischemic time of over 16 h has rarely been described in clinical lung transplantation.
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References
Christie JD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Dobbels F, et al. The registry of the international society for heart and lung transplantation: 29th official adult and heart-lung transplantation report. J Heart Lung Transpl. 2012;31:1073–86.
Okada Y, Matsumura Y, Date H, Bando T, Oto T, Sado T, et al. Clinical application of an extracellular phosphate-buffered solution (EP-TU) for lung preservation: preliminary results of a Japanese series. Surg Today. 2012;42:152–6.
Okada Y, Marchevsky AM, Zuo XJ, Pass J, Kass RM, Matloff JM, et al. Accumulation of platelets in rat syngeneic lung transplants: a potential factor responsible for preservation-reperfusion injury. Transplantation. 1997;64:801–6.
Yoshida O, Yamane M, Yamamoto S, Okazaki M, Toyooka S, Oto T, et al. Surg Today. 2013;43:1–7.
Noda M, Okada Y, Saiki Y, Sado T, Hoshikawa Y, Endo C, et al. Reconstruction of pulmonary artery with donor aorta and auto-pericardium in lung transplantation. Ann Thorac Surg. 2013;96:e17–9.
Thabut G, Mal H, Cerrina J, Dartevelle P, Dromer C, Velly JF, et al. Graft ischemic time and outcome of lung transplantation: a multicenter analysis. Am J Respir Crit Care Med. 2005;171:786–91.
Kuntz CL, Hadjiliadis D, Ahya VN, Kotloff RM, Pochettino A, Lewis J, et al. Risk factors for early primary graft dysfunction after lung transplantation: a registry study. Clin Transpl. 2009;23:819–30.
Handa M, Fujimura S, Kondo T, Ichinose T, Shiraishi Y, Nakada T. A study of preservation solution for 48- and 96-hour simple hypothermic storage of canine lung transplants. Tohoku J Exp Med. 1989;159:205–14.
Okada Y, Kondo T. Preservation solution for lung transplantation. Gen Thorac Cardiovasc Surg. 2009;57:635–9.
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Hisashi Oishi and his coauthors have no conflicts of interest.
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Oishi, H., Okada, Y., Saiki, Y. et al. Successful bilateral lung transplantation after 16 h of lung preservation with EP-TU solution: report of a case. Surg Today 45, 630–633 (2015). https://doi.org/10.1007/s00595-014-0931-3
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DOI: https://doi.org/10.1007/s00595-014-0931-3