Skip to main content

Effect of low central venous pressure on postoperative pulmonary complications in patients undergoing liver transplantation

An Erratum to this article was published on 31 July 2013

Abstract

Purpose

To investigate the effect of the low central venous pressure (LCVP) technique on postoperative pulmonary complications in patients undergoing liver transplantation.

Methods

Sixty-five adult patients were randomly divided into a LCVP group (n = 33) and a control group (n = 32). The CVP was maintained below 5 mmHg or 40 % lower than baseline in the LCVP group, by manipulating the patient’s posture, limiting infusion volume, and administration of nitroglycerine. Recipients in the control group received standard care. The volume of intraoperative blood loss and transfusion, and postoperative pulmonary complications of the two groups were compared.

Results

The LCVP group had a significantly earlier tracheal extubation (33 ± 33 vs. 53 ± 36 h, P < 0.05), and lower rate of postoperative pulmonary complications (42.8 vs. 71.4 %, P < 0.05) in comparison to the control group. The most frequent complication was pleural effusion (28.5 vs. 67.8 %, P < 0.05), followed by pneumonia (24.2 vs. 57.1 %, P < 0.05) and pulmonary edema (3.1 vs. 14.3 %, P < 0.05).

Conclusions

The LCVP technique during liver transplantation could decrease postoperative pulmonary complications.

This is a preview of subscription content, access via your institution.

References

  1. Eguchi S, Soyama A, Hidaka M, Takatsuki M, Muraoka I, Tomonaga T, et al. Liver transplantation for patients with human immunodeficiency virus and hepatitis C virus coinfection with special reference to hemophiliac recipients in Japan. Surg Today. 2011;41(10):1325–31.

    Article  PubMed  Google Scholar 

  2. Golfieri R, Giampalma E, Morselli Labate AM, d’Arienzo P, Jovine E, Grazi GL, et al. Pulmonary complications of liver transplantation: radiological appearance and statistical evaluation of risk factors in 300 cases. Eur Radiol. 2000;10(7):1169–83.

    Article  PubMed  CAS  Google Scholar 

  3. Pirat A, Ozgur S, Torgay A, Candan S, Zeyneloğlu P, Arslan G. Risk factors for postoperative respiratory complications in adult liver transplant recipients. Transplant Proc. 2004;36(1):218–20.

    Article  PubMed  CAS  Google Scholar 

  4. Lin CC, Chuang FR, Wang CC, Chen YS, Chen CL, Liu YW, et al. Early postoperative complications in recipients of living donor liver transplantation. Transplant Proc. 2004;36(8):2338–41.

    Article  PubMed  Google Scholar 

  5. Feng ZY, Xu X, Zhu SM, Bein B, Zheng SS. Effects of low central venous pressure during preanhepatic phase on blood loss and liver and renal function in liver transplantation. World J Surg. 2010;34(8):1864–73.

    Article  PubMed  Google Scholar 

  6. Massicotte L, Lenis S, Thibeault L, Sassine MP, Seal RF, Roy A. Effect of low central venous pressure and phlebotomy on blood product transfusion requirements during liver transplantations. Liver Transpl. 2006;12(4):117–23.

    Article  PubMed  Google Scholar 

  7. Carton EG, Plevak DJ, Kranner PW, Rettke SR, Geiger HJ, Coursin DB. Perioperative care of the liver transplant patient: Part 2. Anesth Analg. 1994;78(2):382–99.

    Article  PubMed  CAS  Google Scholar 

  8. Carton EG, Rettke SR, Plevak DJ, Geiger HJ, Kranner PW, Coursin DB. Perioperative care of the liver transplant patient: Part 1. Anesth Analg. 1994;78(1):120–33.

    Article  PubMed  CAS  Google Scholar 

  9. Schroeder RA, Johnson LB, Plotkin JS, Kuo PC, Klein AS. Total blood transfusion and mortality after orthotopic liver transplantation. Anesthesiology. 1999;91(1):329–30.

    Article  PubMed  CAS  Google Scholar 

  10. Steib A, Freys G, Lehmann C, Meyer C, Mahoudeau G. Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict. Can J Anaesth. 2001;48(11):1075–9.

    Article  PubMed  CAS  Google Scholar 

  11. Hannaman MJ, Hevesi ZG. Anesthesia care for liver transplantation. Transplant Rev (Orlando). 2011;25:36–43.

    Article  Google Scholar 

  12. Hong SK, Hwang S, Lee SG, Lee LS, Ahn CS, Kim KH, et al. Pulmonary complications following adult liver transplantation. Transplant Proc. 2006;38(9):2979–81.

    Article  PubMed  CAS  Google Scholar 

  13. Colbert S, O’Hanlon DM, Duranteau J, Ecoffey C. Cardiac output during liver transplantation. Can J Anaesth. 1998;45(2):133–8.

    Article  PubMed  CAS  Google Scholar 

  14. Shaw BW Jr, Wood RP, Iwatsuki S, Gillquist WP, Starzl TE. Influence of selected patient variables and operative blood loss on six-month survival following liver transplantation. Semin Liver Dis. 1985;5(4):385–93.

    Article  PubMed  Google Scholar 

  15. Jensen WA, Rose RM, Hammer SM, Jenkins RL, Bothe A Jr, Benotti PN, et al. Pulmonary complications of orthotopic liver transplantation. Transplantation. 1986;42(5):484–90.

    Article  PubMed  CAS  Google Scholar 

  16. Duran FG, Piqueras B, Romero M, Carneros JA, de Diego A, Salcedo M, et al. Pulmonary complications following orthotopic liver transplant. Transpl Int. 1998;11(Suppl 1):S255–9.

    Article  PubMed  Google Scholar 

  17. Triulzi DJ. Transfusion-related acute lung injury: current concepts for the clinician. Anesth Analg. 2009;108:770–6.

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Su Min.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wang, B., He, Hk., Cheng, B. et al. Effect of low central venous pressure on postoperative pulmonary complications in patients undergoing liver transplantation. Surg Today 43, 777–781 (2013). https://doi.org/10.1007/s00595-012-0419-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-012-0419-y

Keywords

  • Liver transplantation
  • Low central venous pressure
  • Pulmonary complication
  • Blood loss
  • Transfusion