Skip to main content

Advertisement

SpringerLink
Log in

The central vein access port and catheter in outpatient chemotherapy for colorectal cancer: a retrospective study of 101 patients

  • Original Article
  • Published:
Surgery Today Aims and scope Submit manuscript

An Erratum to this article was published on 14 March 2013

Abstract

Purpose

The central venous access port (CV-port) system was examined in a series of colorectal cancer (CRC) patients.

Methods

One hundred and one CRC patients underwent chemotherapy with the 5-fluorouracil + oxaliplatin (FOLFOX) or 5-fluorouracil + irinotecan regimen. The complications of the CV-port system were retrospectively assessed.

Results

The CV-port system was placed in a total of 101 patients. The patients received a total of 1035 courses of these regimens. Eight complications occurred in the 101 patients (7.9%). The complications included three instances of catheter rupture, two thrombotic events around the catheter, and three infections at the site of the port or catheter. The complications were identified after a median of nine courses (range 6–16) and 135 days after the placement of the CV-port system. Sixty-six of the 101 patients switched their regimen from FOLFOX to another regimen, and 4 of these 66 patients (6.1%) experienced complications associated with the CV-port system. There were 25 subjects who were admitted to the hospital emergency wing during the chemotherapeutic regimens, and 4 of these patients (16%) had complications associated with the CV-port system.

Conclusions

The complications of the CV-port system occurred at a defined rate, therefore the early diagnosis and the appropriate treatment to address these complications is crucial.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Niederhuber JE, Ensminger W, Gyves JW, Liepman M, Doan K, Cozzi E. Totally implanted venous and arterial access system to replace external catheters in cancer treatment. Surgery. 1982;92:706–12.

    PubMed  CAS  Google Scholar 

  2. Torramade JR, Cienfuegos JA, Hernandez JL, Pardo F, Benito C, Gonzalez J, et al. The complications of central venous access systems: a study of 218 patients. Eur J Surg. 1993;159:323–7.

    PubMed  CAS  Google Scholar 

  3. Konno H, Yamamoto M, Ohta M. Recent concepts of antiangiogenic therapy. Surg Today. 2010;40:494–500.

    Article  PubMed  Google Scholar 

  4. Cassidy J, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, et al. Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol. 2008;26:2006–12.

    Article  PubMed  CAS  Google Scholar 

  5. Tsunoda A, Yasuda N, Nakao K, Narita K, Watanabe M, Matsui N, et al. Phase II study of S-1 combined with irinotecan (CPT-11) in patients with advanced colorectal cancer. Oncology. 2009;77:192–6.

    Article  PubMed  CAS  Google Scholar 

  6. Ishida H, Miyake Y, Fukunaga M, Watanabe Y, Kato T, Takemoto H, et al. A feasibility study of UFT/LV and irinotecan (TEGAFIRI) in advanced or metastatic colorectal cancer: Osaka Gastrointestinal Cancer Chemotherapy Study Group (OGSG) PROG 0304. Jpn J Clin Oncol. 2009;39:601–5.

    Article  PubMed  Google Scholar 

  7. Biffi R, de Braud F, Orsi F, Pozzi S, Mauri S, Goldhirsch A, et al. Totally implantable central venous access ports for long-term chemotherapy. A prospective study analyzing complications and costs of 333 devices with a minimum follow-up of 180 days. Ann Oncol. 1998;9:767–73.

    Article  PubMed  CAS  Google Scholar 

  8. Charvat J, Linke Z, Horaekova M, Prausova J. Implantation of central venous ports with catheter insertion via the right internal jugular vein in oncology patients: single center experience. Support Care Cancer. 2006;14:1162–5.

    Article  PubMed  CAS  Google Scholar 

  9. Yip D, Funaki B. Subcutaneous chest ports via the internal jugular vein. A retrospective study of 117 oncology patients. Acta Radiol. 2002;43:371–5.

    Article  PubMed  CAS  Google Scholar 

  10. Funaki B, Szymski GX, Hackworth CA, Rosenblum JD, Burke R, Chang T, et al. Radiologic placement of subcutaneous infusion chest ports for long-term central venous access. AJR Am J Roentgenol. 1997;169:1431–4.

    Article  PubMed  CAS  Google Scholar 

  11. Hinke DH, Zandt-Stastny DA, Goodman LR, Quebbeman EJ, Krzywda EA, Andris DA. Pinch-off syndrome: a complication of implantable subclavian venous access devices. Radiology. 1990;177:353–6.

    PubMed  CAS  Google Scholar 

  12. Andris DA, Krzywda EA, Schulte W, Ausman R, Quebbeman EJ. Pinch-off syndrome: a rare etiology for central venous catheter occlusion. JPEN J Parenter Enter Nutr. 1994;18:531–3.

    Article  CAS  Google Scholar 

  13. Kawamura J, Nagayama S, Nomura A, Itami A, Okabe H, Sato S, et al. Long-term outcomes of peripheral arm ports implanted in patients with colorectal cancer. Int J Clin Oncol. 2008;13:349–54.

    Article  PubMed  Google Scholar 

  14. Fazeny-Dorner B, Wenzel C, Berzlanovich A, Sunder-Plassmann G, Greinix H, Marosi C, et al. Central venous catheter pinch-off and fracture: recognition, prevention and management. Bone Marrow Transplant. 2003;31:927–30.

    Article  PubMed  CAS  Google Scholar 

  15. De Cicco M, Matovic M, Balestreri L, Panarello G, Fantin D, Morassut S, et al. Central venous thrombosis: an early and frequent complication in cancer patients bearing long-term silastic catheter. A prospective study. Thromb Res. 1997;86:101–13.

    Article  PubMed  Google Scholar 

  16. Cortelezzi A, Moia M, Falanga A, Pogliani EM, Agnelli G, Bonizzoni E, et al. Incidence of thrombotic complications in patients with haematological malignancies with central venous catheters: a prospective multicentre study. Br J Haematol. 2005;129:811–7.

    Article  PubMed  Google Scholar 

  17. Verso M, Agnelli G, Bertoglio S, Di Somma FC, Paoletti F, Ageno W, et al. Enoxaparin for the prevention of venous thromboembolism associated with central vein catheter: a double-blind, placebo-controlled, randomized study in cancer patients. J Clin Oncol. 2005;23:4057–62.

    Article  PubMed  CAS  Google Scholar 

  18. Couban S, Goodyear M, Burnell M, Dolan S, Wasi P, Barnes D, et al. Randomized placebo-controlled study of low-dose warfarin for the prevention of central venous catheter-associated thrombosis in patients with cancer. J Clin Oncol. 2005;23:4063–9.

    Article  PubMed  CAS  Google Scholar 

  19. Karthaus M, Kretzschmar A, Kroning H, Biakhov M, Irwin D, Marschner N, et al. Dalteparin for prevention of catheter-related complications in cancer patients with central venous catheters: final results of a double-blind, placebo-controlled phase III trial. Ann Oncol. 2006;17:289–96.

    Article  PubMed  CAS  Google Scholar 

  20. Vescia S, Baumgartner AK, Jacobs VR, Kiechle-Bahat M, Rody A, Loibl S, et al. Management of venous port systems in oncology: a review of current evidence. Ann Oncol. 2008;19:9–15.

    Article  PubMed  CAS  Google Scholar 

  21. Bouza E, Burillo A, Munoz P. Catheter-related infections: diagnosis and intravascular treatment. Clin Microbiol Infect. 2002;8:265–74.

    Article  PubMed  CAS  Google Scholar 

  22. Ouriel K. Preventing complications of central venous catheterization. N Engl J Med. 2003;348:2684–6 (author reply 2684–6).

    Google Scholar 

  23. Kovacevich DS, Papke LF. Guidelines for the prevention of intravascular catheter-related infections: Centers for Disease Control and Prevention. Nutr Clin Pract. 2003;18:95–6.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan

    Hiroshi Sawayama, Naoko Hayashi, Masayuki Watanabe, Hiroshi Takamori, Toru Beppu & Hideo Baba

Authors
  1. Hiroshi Sawayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Naoko Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masayuki Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hiroshi Takamori
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Toru Beppu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hideo Baba
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hideo Baba.

Additional information

An erratum to this article can be found online at http://dx.doi.org/10.1007/s00595-013-0552-2.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sawayama, H., Hayashi, N., Watanabe, M. et al. The central vein access port and catheter in outpatient chemotherapy for colorectal cancer: a retrospective study of 101 patients. Surg Today 42, 29–34 (2012). https://doi.org/10.1007/s00595-011-0016-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-011-0016-5

Keywords

Search

Navigation