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Antimicrobial prophylaxis and colon preparation for colorectal surgery: Results of a questionnaire survey of 721 certified institutions in Japan

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Antimicrobial prophylaxis (AMP) can reduce the risk of surgical site infection (SSI) in gastroenterological surgery; however, in Japan its use was not fully recognized before 2000. The first nationwide guideline was published in 2001, since when the use of AMP has improved gradually. We conducted this study to investigate the current implementation of AMP in colorectal surgery and adherence to recommended practices for preventing SSI in Japan.


A questionnaire survey was sent to hospitals accredited by the Japanese Society of Gastroenterological Surgery and the Japan Society for Surgical Infection (JSSI). The questionnaire focused on the AMP regimen used for colorectal surgery.


Responses were received from 721 (58%) of the 1249 hospitals that were sent the survey. The initial AMP dose was administered within 1 h before incision at 94% of the responding institutions. AMP was discontinued within 24 h of surgery at only 10% of institutions. Second-generation cephalosporins were administered at 84% of the institutions.


The appropriate use of AMP in colorectal surgery is incomplete in certified institutions in Japan. The fact that many institutions administer AMP for longer than recommended is a problem that needs to be addressed.

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Kobayashi, M., Takesue, Y., Kitagawa, Y. et al. Antimicrobial prophylaxis and colon preparation for colorectal surgery: Results of a questionnaire survey of 721 certified institutions in Japan. Surg Today 41, 1363–1369 (2011).

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