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Resection of lung metastases from hepatocellular carcinoma after living donor liver transplantation: Report of two cases

Surgery Today volume 41, Article number: 1294 (2011) Cite this article

Abstract

Hepatocellular carcinoma (HCC) recurrence after liver transplantation is associated with a poor prognosis; nonetheless, we report two cases of long-term survival after resection of pulmonary metastatic lesions following living donor liver transplantation (LDLT). The intervals between LDLT and pulmonary resection for the metastatic lesion were 24 months and 30 months, respectively. Regular checking of tumor markers and prompt workup for early detection may contribute to the resectability of such metastatic lesions. These cases suggest that resection of a solitary metastatic lesion in the lung from HCC after liver transplantation may be a feasible treatment for selected patients.

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References

  1. Mazzafero V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996;334:693–699.

    Article  Google Scholar 

  2. Yoshimura N, Okajima H, Ushigome H, Sakamoto S, Fujiki M, Okamoto M. Current status of organ transplantation in Japan and worldwide. Surg Today 2010;40:514–525.

    PubMed  Article  Google Scholar 

  3. Sugawara Y, Kokudo N. Surgical treatment of hepatocellular carcinoma: comparison of resection and transplantation. Oncology 2008;75:119–123.

    PubMed  Article  Google Scholar 

  4. Sugawara Y, Tamura S, Makuuchi M. Living donor liver transplantation for hepatocellular carcinoma: Tokyo University series. Dig Dis 2007;25:310–312.

    PubMed  Article  Google Scholar 

  5. Hwang S, Lee SG, Joh JW, Suh KS, Kim DG. Liver transplantation for adult patients with hepatocellular carcinoma in Korea: comparison between cadaveric donor and living donor liver transplantation. Liver Transpl 2005;11:1265–1272.

    PubMed  Article  Google Scholar 

  6. Todo S, Furukawa H; Japanese Study Group on Organ Transplantation. Living donor liver transplantation for adult patients with hepatocellular carcinoma: experience in Japan. Ann Surg 2004;240: 451–459.

    PubMed  Article  Google Scholar 

  7. Kornberg A, Küpper B, Tannapfel A, Katenkamp K, Thrum K, Habrecht O, et al. Long-term survival after recurrent hepatocellular carcinoma in liver transplant patients: clinical patterns and outcome variables. Eur J Surg Oncol 2010;36:275–280.

    PubMed  CAS  Google Scholar 

  8. Roberts JP. Tumor surveillance — what can and should be done? Screening for recurrence of hepatocellular carcinoma after liver transplantation. Liver Transpl 2005;11:S45–S46.

    PubMed  Article  Google Scholar 

  9. Regalia E, Fassati LR, Valente U, Pulvirenti A, Damilano I, Dardano G, et al. Pattern and management of recurrent hepatocellular carcinoma after liver transplantation. J Hepatobiliary Pancreat Surg 1998;5:29–34.

    PubMed  Article  CAS  Google Scholar 

  10. Hwang S, Lee SG, Ahn CS, Kim KH, Moon DB, Ha TY, et al. Small-sized liver graft does not increase the risk of hepatocellular carcinoma recurrence after living donor liver transplantation. Transplant Proc 2007;39:1526–1529.

    PubMed  Article  CAS  Google Scholar 

  11. Roayaie S, Schwartz JD, Sung MW, Emre SH, Miller CM, Gondolesi GE, et al. Recurrence of hepatocellular carcinoma after liver transplant: patterns and prognosis. Liver Transpl 2004;10:534–540.

    PubMed  Article  Google Scholar 

  12. Bates MJ, Farkas E, Taylor D, McFadden PM. Pulmonary resection of metastatic hepatocellular carcinoma after liver transplantation. Ann Thorac Surg 2008;85:412–415.

    PubMed  Article  Google Scholar 

  13. Urata K, Kawasaki S, Matsunami H, Hashikura Y, Ikegami T, Ishizone S, et al. Calculation of child and adult standard liver volume for liver transplantation. Hepatology 1995;21:1317–1321.

    PubMed  Article  CAS  Google Scholar 

  14. Ito T, Takada Y, Ueda M, Haga H, Maetani Y, Oike F, et al. Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation. Liver Transpl 2007;13: 1637–1644.

    PubMed  Article  Google Scholar 

  15. Roxburgh P, Evans TR. Systemic therapy of hepatocellular carcinoma: are we making progress? Adv Ther 2008;25:1089–1104.

    PubMed  Article  CAS  Google Scholar 

  16. Bazan HA, McMurtry KA, Waters PF, Thung SN. Surgical resection of pulmonary metastases after orthotopic liver transplantation for hepatocellular carcinoma. Transplantation 2002;73: 1007–1008.

    PubMed  Article  Google Scholar 

  17. Viola C, Asselah T, Samuel D, Durand F, Boudjema H, Valla D, et al. Solitary pulmonary metastasis arising thirteen years after liver transplantation for HBV-related hepatocellular carcinoma. World J Gastroenterol 2006;12:4911–4913.

    PubMed  Google Scholar 

  18. Zhang C, Rao J, Tu Z, Ni Y. Surgical resection of resectable thoracic metastatic hepatocellular carcinoma after liver transplantation. J Thorac Cardiovasc Surg 2009;138:240–241.

    PubMed  Article  Google Scholar 

  19. Asaoka T, Marubashi S, Dono K, Hama N, Kim C, Kobayashi S, et al. Management of pulmonary recurrence of hepatocellular carcinoma after receiving a living-donor liver transplantation — a case report (in Japanese). Gan to Kagakuryoho (Jpn J Cancer Chemother) 2008;35:2086–2087.

    Google Scholar 

  20. Lam CM, Lo CM, Yuen WK, Liu CL, Fan ST. Prolonged survival in selected patients following surgical resection for pulmonary metastasis from hepatocellular carcinoma. Br J Surg 1998;85: 1198–1200.

    PubMed  Article  CAS  Google Scholar 

  21. Tomimaru Y, Sasaki Y, Yamada T, Eguchi H, Takami K, Ohigashi H, et al. The significance of surgical resection for pulmonary metastasis from hepatocellular carcinoma. Am J Surg 2006;192:46–51.

    PubMed  Article  Google Scholar 

  22. Nakajima J, Tanaka M, Matsumoto J, Takeuchi E, Fukami T, Takamoto S. Appraisal of surgical treatment for pulmonary metastasis from hepatocellular carcinoma. World J Surg 2005;29:715–718.

    PubMed  Article  Google Scholar 

  23. Nakamura T, Kimura T, Umehara Y, Suzuki K, Okamoto K, Okumura T, et al. Long-term survival after report resection of pulmonary metastases from hepatocellular carcinoma: report of two cases. Surg Today 2005;35:890–892.

    PubMed  Article  Google Scholar 

  24. Yamashiki N, Sugawara Y, Tamura S, Tateishi R, Yoshida H, Kaneko J, et al. Postoperative surveillance with monthly serum tumor markers after living-donor liver transplantation for hepatocellular carcinoma. Hepatol Res 2010;40:278–286.

    PubMed  Article  Google Scholar 

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Affiliations

  1. Artificial Organ and Transplantation Division, Department of Surgery, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Junichi Togashi, Yasuhiko Sugawara, Taku Aoki, Sumihito Tamura, Junichi Kaneko & Norihiro Kokudo

  2. Department of Cardiothoracic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Jun Nakajima & Atsushi Sano

Authors
  1. Junichi Togashi
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  2. Yasuhiko Sugawara
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  3. Taku Aoki
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  4. Sumihito Tamura
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  5. Junichi Kaneko
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  6. Jun Nakajima
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  7. Atsushi Sano
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  8. Norihiro Kokudo
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Togashi, J., Sugawara, Y., Aoki, T. et al. Resection of lung metastases from hepatocellular carcinoma after living donor liver transplantation: Report of two cases. Surg Today 41, 1294 (2011). https://doi.org/10.1007/s00595-010-4487-6

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  • DOI: https://doi.org/10.1007/s00595-010-4487-6

Key words

  • Hepatocellular carcinoma
  • Lung metastasis
  • Resection