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Plasma high-mobility group box 1 as an indicator of surgical stress

Surgery Today volume 41, pages 903–907 (2011)Cite this article

Abstract

Purpose

High-mobility group box 1 (HMGB-1) is a late-phase cytokine, which is released extracellularly in response to systemic inflammation caused by infection, shock, or trauma. We examined the plasma levels of HMGB-1 to clarify its role in surgical stress.

Methods

The subjects of this study were 37 patients who underwent elective general surgery. We measured plasma concentrations of HMGB-1 over time using a quantitative enzyme-linked immunosorbent assay. We then analyzed the relationships between the change in HMGB-1 concentration and perioperative factors, including postoperative complications. Statistical analyses were performed using two-way repeated-measures analysis of variance.

Results

The HMGB-1 level was higher on postoperative day 3 in patients with a prolonged operative time or large intraoperative blood loss (P = 0.048 and P = 0.041, respectively). The HMGB-1 level also remained high over time in patients with postoperative complications (P = 0.037).

Conclusions

These results show that the plasma HMGB-1 level is related to surgical stress such as operative time and blood loss. The level remained high over time in patients with postoperative complication, suggesting progression of the complication.

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Affiliations

  1. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Atsushi Osoegawa, Tokujiro Yano, Tetsuzo Tagawa, Fumihiro Shoji, Akinobu Taketomi, Hiroyuki Ito, Yoshihiro Kakeji & Yoshihiko Maehara

  2. Division of Cancer Statistics, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan

    Takeharu Yamanaka

  3. Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan

    Ichiro Yoshino

  4. Department of Surgery, Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital, 1-9-6 Senda-machi, Naka-ku, Hiroshima, 730-8619, Japan

    Atsushi Osoegawa

Authors
  1. Atsushi Osoegawa
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  2. Tokujiro Yano
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  3. Takeharu Yamanaka
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  4. Tetsuzo Tagawa
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  5. Fumihiro Shoji
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  6. Ichiro Yoshino
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  7. Akinobu Taketomi
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  8. Hiroyuki Ito
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  9. Yoshihiro Kakeji
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  10. Yoshihiko Maehara
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Osoegawa, A., Yano, T., Yamanaka, T. et al. Plasma high-mobility group box 1 as an indicator of surgical stress. Surg Today 41, 903–907 (2011). https://doi.org/10.1007/s00595-010-4371-4

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  • DOI: https://doi.org/10.1007/s00595-010-4371-4

Key words

  • Plasma high-mobility group box 1
  • Surgical stress
  • Perioperative period
  • Postoperative complications