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Multiple solitary leiomyomas in the esophagus: Report of a case

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Abstract

We herein report our findings for an asymptomatic 65-year-old man presenting with multiple solitary leiomyomas in the esophagus, who was undergoing follow-up for primary aldosteronism with high levels of serum progesterone. Esophageal endoscopy and computed tomography showed multiple submucosal tumors with calcification in the thoracic esophagus. A subtotal esophagectomy was performed because the possibility of malignancy could not be ruled out based on a needle biopsy taken of the specimen. The final resected specimen showed eight solitary, encapsulated nodules between the middle and lower thoracic esophagus. Histopathological examinations showed these nodules to have the typical histological findings of leiomyomas. In addition, staining with antibodies against the progesterone receptor revealed diffuse expression in the nuclei of the leiomyoma cells. Only four cases with more than eight solitary leiomyomas have been reported, including the current case. However, this is the first reported case where primary aldosteronism with elevated serum progesterone levels has been implicated in the pathogenesis of multiple solitary leiomyomas in the esophagus.

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Authors and Affiliations

  1. Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Yoshinaga Okugawa, Yasuhiko Mohri, Yuji Toiyama, Takeshi Yokoe, Masaki Ohi, Koji Tanaka & Masato Kusunoki

  2. Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    Katsunori Uchida & Taizo Shiraishi

Authors
  1. Yoshinaga Okugawa
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  2. Yasuhiko Mohri
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  3. Yuji Toiyama
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  4. Takeshi Yokoe
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  5. Masaki Ohi
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  6. Koji Tanaka
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  7. Katsunori Uchida
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  8. Taizo Shiraishi
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  9. Masato Kusunoki
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Okugawa, Y., Mohri, Y., Toiyama, Y. et al. Multiple solitary leiomyomas in the esophagus: Report of a case. Surg Today 41, 563–567 (2011). https://doi.org/10.1007/s00595-010-4286-0

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  • DOI: https://doi.org/10.1007/s00595-010-4286-0

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