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Primary colorectal signet-ring cell carcinoma: Clinicopathological features and postoperative survival

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Abstract

Purpose

The objective of this study was to investigate the clinicopathological features and postoperative survival of primary colorectal signet-ring cell carcinoma.

Methods

Nineteen patients with primary colorectal signet-ring cell carcinoma were identified from a database of 5884 surgical patients with colorectal cancers treated surgically at Osaka University Hospital and affiliated hospitals between 1993 and 2007. The clinicopathological data of those patients were compared with those of 5792 patients with non-signet-ring cell colorectal carcinoma (5417 with well or moderately differentiated adenocarcinoma and 375 with poorly differentiated adenocarcinoma or mucinous carcinoma).

Results

All patients showed a tumor depth of over T3. Lymph node involvement occurred in 14 patients. Seven of 19 patients presented with distant metastasis at the time of diagnosis. The overall 5-year survival rate in primary signet-ring cell carcinoma was significantly lower at 24.1%, in comparison to 77.5% in well or moderately differentiated adenocarcinoma and 57.7% in poorly differentiated adenocarcinoma or mucinous carcinoma. Likewise, the postoperative survival in Stage III was also significantly worse. On the other hand, no significant difference was observed in Stage II or IV.

Conclusion

The most important feature of primary colorectal signet-ring cell carcinoma is the advanced stage at the time of diagnosis. In addition, the postoperative survival is worse than for other types of colorectal cancer.

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References

  1. Laufman H, Saphir O. Primary linitis plastica type of carcinoma of the colon. AMA Arch Surg 1951;62:79–91.

    CAS  PubMed  Google Scholar 

  2. Tung SY, Wu CS, Chen PC. Primary signet ring cell carcinoma of colorectum: an age- and sex-matched controlled study. Am J Gastroenterol 1996;91:2195–2199.

    CAS  PubMed  Google Scholar 

  3. Almagro UA. Primary signet-ring carcinoma of the colon. Cancer 1983;52:1453–1457.

    Article  CAS  PubMed  Google Scholar 

  4. Giacchero A, Aste H, Baracchini P, Conio M, Fulcheri E, Lapertosa G, et al. Primary signet-ring carcinoma of the large bowel. Report of nine cases. Cancer 1985;56:2723–2726.

    Article  CAS  PubMed  Google Scholar 

  5. Secco GB, Fardelli R, Campora E, Lapertosa G, Gentile R, Zoli S, et al. Primary mucinous adenocarcinomas and signet-ring cell carcinomas of colon and rectum. Oncology 1994;51:30–34.

    Article  CAS  PubMed  Google Scholar 

  6. Anthony T, George R, Rodriguez-Bigas M, Petrelli NJ. Primary signet-ring cell carcinoma of the colon and rectum. Ann Surg Oncol 1996;3:344–348.

    Article  CAS  PubMed  Google Scholar 

  7. Messerini L, Palomba A, Zampi G. Primary signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum 1995;38:1189–1192.

    Article  CAS  PubMed  Google Scholar 

  8. Nissan A, Guillem JG, Paty PB, Wong WD, Cohen AM. Signetring cell carcinoma of the colon and rectum: a matched control study. Dis Colon Rectum 1999;42:1176–1180.

    Article  CAS  PubMed  Google Scholar 

  9. Ooi BS, Ho YH, Eu KW, Seow CF. Primary colorectal signet-ring cell carcinoma in Singapore. Aust NZ J Surg 2001;71:703–706.

    Article  CAS  Google Scholar 

  10. Bittorf B, Merkel S, Matzel KE, Wein A, Dimmler A, Hohenberger W. Primary signet-ring cell carcinoma of the colorectum. Langenbecks Arch Surg 2004;389:178–183.

    Article  PubMed  Google Scholar 

  11. Makino T, Tsujinaka T, Mishima H, Ikenaga M, Sawamura T, Nakamori S, et al. Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases. Hepatogastroenterology 2006;53:845–849.

    PubMed  Google Scholar 

  12. Psathakis D, Schiedeck TH, Krug F, Oevermann E, Kujath P, Bruch HP. Ordinary colorectal adenocarcinoma vs. primary colorectal signet-ring cell carcinoma: study matched for age, gender, grade, and stage. Dis Colon Rectum 1999;42:1618–1625.

    Article  CAS  PubMed  Google Scholar 

  13. Li C, Kim S, Lai JF, Hyung WJ, Choi WH, Choi SH, et al. Advanced gastric carcinoma with signet ring cell histology. Oncology 2007;72:64–68.

    Article  PubMed  Google Scholar 

  14. Pande R, Sunga A, Levea C, Wilding GE, Bshara W, Reid M, et al. Significance of signet-ring cells in patients with colorectal cancer. Dis Colon Rectum 2008;51:50–55.

    Article  PubMed  Google Scholar 

  15. de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000;18:2938–2947.

    PubMed  Google Scholar 

  16. Saltz LB, Cox JV, Blanke C, Rosen LS, Fehrenbacher L, Moore MJ, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 2000;343:905–914.

    Article  CAS  PubMed  Google Scholar 

  17. Tournigand C, André T, Achille E, Lledo G, Flesh M, Mery-Mignard D, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004;22:229–237.

    Article  CAS  PubMed  Google Scholar 

  18. Moertel CG, Fleming TR, Macdonald JS, Haller DG, Laurie JA, Goodman PJ, et al. Levamisole and fluorouracil as adjuvant therapy of resected colon carcinoma. N Engl J Med 1990;322:352–358.

    Article  CAS  PubMed  Google Scholar 

  19. André T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004;350:2343–2351.

    Article  PubMed  Google Scholar 

  20. Badgwell B, Cormier JN, Krishnan S, Yao J, Staerkel GA, Lupo PJ, et al. Does neoadjuvant treatment for gastric cancer patients with positive peritoneal cytology at staging laparoscopy improve survival? Ann Surg Oncol 2008;15:2684–2691.

    Article  PubMed  Google Scholar 

  21. Ikeguchi M, Miyake T, Matsunaga T, Yamamoto M, Fukumoto Y, Yamada Y, et al. Recent results of therapy for scirrhous gastric cancer. Surg Today 2009;39:290–294.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Rinku General Medical Center, Izumisano Municipal Hospital, Izumisano, Osaka, Japan

    Tsunekazu Mizushima & Hitoshi Mizuno

  2. Department of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Tsunekazu Mizushima, Kiyokazu Nakajima & Toshirou Nishida

  3. Department of Surgery, Osaka General Medical Center, Osaka, Japan

    Masaya Nomura

  4. Department of Surgery, Osaka Kosei-Nenkin Hospital, Osaka, Japan

    Makoto Fujii

  5. Department of Surgery, Osaka Police Hospital, Osaka, Japan

    Hiroki Akamatsu

  6. Department of Surgery, National Hospital Organization Kure Medical Center, Kure, Hiroshima, Japan

    Harumi Tominaga

  7. Department of Surgery, Osaka Rosai Hospital, Sakai, Osaka, Japan

    Junichi Hasegawa

  8. Department of Surgery, Nissei Hospital, Osaka, Japan

    Keigo Yasumasa

  9. Department of Surgery, Osaka Central Hospital, Osaka, Japan

    Masato Yoshikawa

Authors
  1. Tsunekazu Mizushima
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  2. Masaya Nomura
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  3. Makoto Fujii
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  4. Hiroki Akamatsu
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  5. Hitoshi Mizuno
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  6. Harumi Tominaga
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  7. Junichi Hasegawa
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  8. Kiyokazu Nakajima
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  9. Keigo Yasumasa
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  10. Masato Yoshikawa
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  11. Toshirou Nishida
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Mizushima, T., Nomura, M., Fujii, M. et al. Primary colorectal signet-ring cell carcinoma: Clinicopathological features and postoperative survival. Surg Today 40, 234–238 (2010). https://doi.org/10.1007/s00595-009-4057-y

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  • DOI: https://doi.org/10.1007/s00595-009-4057-y

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