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Solitary splenic metastasis from early gastric cancer: Report of a case

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Abstract

Solitary metastasis of a malignancy to the spleen is rare. We herein describe a case of splenic metastasis from early gastric cancer. A 76-year-old man underwent an endoscopic mucosal resection (EMR) for early gastric carcinoma in the cardia. Pathologically, the tumor showed invasion into the submucosal layer, and the stump of the surgical specimen appeared to be positive for malignant cells. He thus underwent a proximal gastrectomy with nodal dissection. One year later, serum carcinoembryonic antigen was elevated, and a splenic mass was detected by computed tomography and ultrasonography. Because the tumor increased in size very gradually and no metastatic lesions were detected at the other sites, we performed a splenectomy. The lesion was pathologically diagnosed as metastasis from the previous gastric carcinoma, and the patient remains healthy to date without recurrence, more than 2 years after the splenectomy. When solitary metastasis to the spleen is suspected during the postoperative follow-up of a patient with gastric cancer, a splenectomy is a potentially effective treatment.

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References

  1. Berge T. Splenic metastases. Frequencies and patterns. Acta Pathol Microbiol Scand [A] 1974;82(4):499–506.

    CAS  Google Scholar 

  2. Lam KY, Tang V. Metastatic tumors to the spleen: a 25-year clinicopathologic study. Arch Pathol Lab Med 2000;124(4):526–530.

    CAS  PubMed  Google Scholar 

  3. Schon CA, Gorg C, Ramaswamy A, Barth PJ. Splenic metastases in a large unselected autopsy series. Pathol Res Pract 2006;202(5):351–356.

    Article  PubMed  Google Scholar 

  4. Alloni R, Garberini A, Caputo D, Coppola R. Solitary splenic metastasis of ovarian carcinoma: report of two cases. Surg Today 2008;38(12):1144–1147.

    Article  PubMed  Google Scholar 

  5. Williams L, Kumar A, Aggarwal S. Calcified splenic metastasis from gastric carcinoma. Abdom Imaging 1995;20(4):312–314.

    Article  CAS  PubMed  Google Scholar 

  6. Opocher E, Santambrogio R, Bianchi P, Cioffi U, De Simone M, Vellini S, et al. Isolated splenic metastasis from gastric carcinoma: value of CEA and CA 19-9 in early diagnosis: report of two cases. Am J Clin Oncol 2000;23(6):579–580.

    Article  CAS  PubMed  Google Scholar 

  7. Yamanouchi K, Ikematsu Y, Waki S, Kida H, Nishiwaki Y, Gotoh K, et al. Solitary splenic metastasis from gastric cancer: report of a case. Surg Today 2002;32(12):1081–1084.

    Article  PubMed  Google Scholar 

  8. Miller JN, Milton GW. An experimental comparison between tumour growth in the spleen and liver. J Pathol Bacteriol 1965;90(2):515–521.

    Article  CAS  PubMed  Google Scholar 

  9. Giraldi T, Sava G, Kopitar M, Brzin J, Suhar A, Turk V. Antimetastatic effects and tumor proteinase inhibition by spleen intracellular inhibitors of neutral proteinases. Eur J Cancer Clin Oncol 1981;17(12):1301–1306.

    Article  CAS  PubMed  Google Scholar 

  10. Ichiyoshi Y, Toda T, Minamisono Y, Nagasaki S, Yakeishi Y, Sugimachi K. Recurrence in early gastric cancer. Surgery 1990;107(5):489–495.

    CAS  PubMed  Google Scholar 

  11. Sano T, Sasako M, Kinoshita T, Maruyama K. Recurrence of early gastric cancer. Follow-up of 1475 patients and review of the Japanese literature. Cancer 1993;72(11):3174–3178.

    Article  CAS  PubMed  Google Scholar 

  12. Suzuki S, Kosugi S, Kuwabara S, Ueki K, Oka Y, Nishimaki T, et al. Tumor recurrence in patients with early gastric cancer: a clinicopathologic evaluation. J Exp Clin Cancer Res 1998;17(2):187–191.

    CAS  PubMed  Google Scholar 

  13. Lee HJ, Kim YH, Kim WH, Lee KU, Choe KJ, Kim JP, et al. Clinicopathological analysis for recurrence of early gastric cancer. Jpn J Clin Oncol 2003;33(5):209–214.

    Article  PubMed  Google Scholar 

  14. Oda I, Saito D, Tada M, Iishi H, Tanabe S, Oyama T, et al. A multicenter retrospective study of endoscopic resection for early gastric cancer. Gastric Cancer 2006;9(4):262–270.

    Article  PubMed  Google Scholar 

  15. Tanaka M, Ono H, Hasuike N, Takizawa K. Endoscopic submucosal dissection of early gastric cancer. Digestion 2008;77suppl 1:23–28.

    Article  PubMed  Google Scholar 

  16. Kim JJ, Lee JH, Jung HY, Lee GH, Cho JY, Ryu CB, et al. EMR for early gastric cancer in Korea: a multicenter retrospective study. Gastrointest Endosc 2007;66(4):693–700.

    Article  PubMed  Google Scholar 

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Kawasaki, H., Kitayama, J., Ishigami, H. et al. Solitary splenic metastasis from early gastric cancer: Report of a case. Surg Today 40, 60–63 (2010). https://doi.org/10.1007/s00595-008-4002-5

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  • DOI: https://doi.org/10.1007/s00595-008-4002-5

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