Abstract
We herein report a case of early primary duodenal carcinoma arising from Brunner’s glands synchronously occurring with sigmoid colon carcinoma. A 65-year-old man with a 5-year history of diabetes mellitus and benign prostatic hypertrophy was admitted to our hospital to undergo a resection of sigmoid colon carcinoma in December 2000. Upper gastrointestinal endoscopy, which was performed as routine preoperative screening, revealed an elevated submucosal-tumor-like lesion with a shallow central depression in the anterior wall of the duodenal bulb. A partial duodenectomy with a partial gastrectomy including No. 5 and No. 6 lymph node dissection and a sigmoidectomy were thus performed. The patient’s postoperative course was uneventful. The histopathology of the resected duodenal specimen revealed the tumor to be an adenocarcinoma arising from Brunner’s glands. The patient has remained diseasefree and has shown no relapse for 6 years postoperatively. Because duodenal carcinoma arising from Brunner’s glands is very rare, we report our case with a review of 25 similar documented cases.
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Kleinerman J, Yardumian K, Tamaki HT. Primary carcinoma of the duodenum. Ann Intern Med 1950;32:451–458.
Iovine VH, Tsangaris N. Primary cancer of the duodenum. Ann Surg 1961;27:744–751.
Shorrock K, Haldane JS, Kersham MJ, Leach RD. Obstructive jaundice secondary to carcinoma arising in Brunner’s glands. J R Soc Med 1986;79:173–174.
Miyamoto T, Matsuba S, Yokohama Y, Makoto I, Toshihiko T, Muneaki S, et al. Early duodenal cancer supposedly arising from the Brunner’s gland, report of case (in Japanese with English abstract). I To Cho (Stomach and Intestine) 1991;26:1395–1399.
Itsuno M, Makiyama K, Omagari K, Tanaka T, Hara K, Tsuda N, et al. Carcinoma of duodenal bulb arising from the Brunner’s gland. Gastroenterol Jpn 1993;28:118–125.
Ajioka Y, Watanabe H, Narisawa R, Iwabuti M, Kobayashi M, Maeo S, et al. Primary duodenal tumors and tumor-like lesions, focused on their incidence and Brunner’s gland adenoma (in Japanese with English abstract). I To Cho (Stomach and Intestine) 1993;28:627–638.
Kawamoto K, Motooka M, Hirata N, Masuda K, Ueyama T, Yasukouchi A, et al. Early primary carcinoma of the duodenal bulb arising from Brunner’s glands. Gastrointest Endosc 1994;40:233–236.
Kushima R, Stolte M, Dirks K, Vieth M, Okabe H, Borchard F, et al. Gastric-type adenocarcinoma of duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner’s glands. Virchows Arch 2002;440:655–659.
Akino K, Kondo Y, Ueno A, Yamazaki K, Hosokawa M, Shimoji H, et al. Carcinoma of duodenum arising from Brunner’s gland. J Gastroenterol 2002;37:293–296.
Miyamoto T, Oshima I, Ozaki M, Ariga T, Kinoshita H, Yoshimura S, et al. A case of duodenal signet-ring cell carcinoma suspected to originate in Brunner’s gland (in Japanese with English abstract). Nihon Syokakigeka Gakkaizasshi (Jpn J Gastroenterol Surg) 2003;36:260–265.
Brookes MJ, Manjunatha S, Allen CA, Cox M. Malignant potential in a Brunner’s gland hamartoma. Postgrad Med J 2003;79:416–417.
Sakurai T, Sakashita H, Honjo G, Kasyu I, Manabe T. Gastric foveolar metaplasia with dysplastic changes in Brunner gland hyperplasia: possible precursor lesions for Brunner gland adenocarcinoma. Am J Surg Pathol 2005;29:1442–1448.
Ota H, Katsuyama T, Ishii K, Nakayama J, Shiozawa T, Tsukahara Y. A dual staining method for identifying mucins of different gastric epithelial mucous cells. Histochem J 1991;23:22–28.
Katsuyama T, Ono K, Nakayama J, Kanai M. Recent advances in mucosubstance histochemistry. In: Kawai K, editor. Gastric mucous and mucous secreting cells. Amsterdam: Excerpta Medica; 1985. p. 3–18.
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Ohta, Y., Saitoh, K., Akai, T. et al. Early primary duodenal carcinoma arising from Brunner’s glands synchronously occurring with sigmoid colon carcinoma: Report of a case. Surg Today 38, 756–760 (2008). https://doi.org/10.1007/s00595-007-3707-1
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DOI: https://doi.org/10.1007/s00595-007-3707-1