Abstract
Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign breast disease. Pseudoangiomatous stromal hyperplasia is characterized by a collagenous proliferation of mammary stroma, associated with capillary-like spaces. We herein report the case of a 48-year-old woman who presented with a huge mass in her right breast. Physical examination revealed a 20 × 23-cm mass, which was surgically excised. Histopathologically, the tumor was composed of abundant fibrous stroma containing non-vascular slit-like spaces and scattered ducts and lobules. Neither stromal nor epithelial cells showed atypia. We therefore diagnosed the tumor to be PASH.
Similar content being viewed by others
References
Vuitch MF, Rosen PP, Erlandson RA. Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol 1986;17:185–191.
Ibrahim RE, Sciotto CG, Weidner N. Pseudoangiomatous hyperplasia of mammary stroma. Some observations regarding its clinicopathologic spectrum. Cancer 1989;63:1154–1160.
Anderson C, Ricci A Jr, Pedersen CA, Cartun RW. Immunocytochemical analysis of estrogen and progesterone receptors in benign stromal lesions of the breast. Evidence for hormonal etiology in pseudoangiomatous hyperplasia of mammary stroma. Am J Surg Pathol 1991;15:145–149.
Zanella M, Falconieri G, Lamovec J, Bittesini L. Pseudoangiomatous hyperplasia of the mammary stroma: true entity or phenotype? Pathol Res Pract 1998;194:535–540.
Cohen MA, Morris EA, Rosen PP, Dershaw DD, Liberman L, Abramson AF. Pseudoangiomatous stromal hyperplasia: mammographic, sonographic, and clinical patterns. Radiology 1996;198:117–120.
Milanezi MF, Saggioro FP, Zanati SG, Bazan R, Schmitt FC. Pseudoangiomatous hyperplasia of mammary stroma associated with gynaecomastia. J Clin Pathol 1998;51:204–206.
Moriya T, Endoh M, Semba S. Pseudoangiomatous stromal hyperplasia (PASH). Byouri to Rinsyo 2001;19:518–520.
Powel CM, Cranor ML, Rosen PP. Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation. Am J Surg Pathol 1995;19:270–277.
Mercado CL, Naidrich SA, Hamele-Bena D, Fineberg SA, Buchbinder SS. Pseudoangiomatous stromal hyperplasia of the breast: sonographic features with histopathologic correlation. Breast J 2004;10:427–432.
Salvador R, Lirola JL, Dominguez R, Lopez M, Risueno N. Pseudoangiomatous stromal hyperplasia presenting as a breast mass: imaging findings in three patients. Breast 2004;13:431–435.
Lui PC, Law BK, Chu WC, Pang LM, Tse GM. Fine-needle aspiration cytology of Pseudoangiomatous stromal hyperplasia of the breast. Diagn Cytopathol 2004;30:353–355.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sasaki, Y., Kamata, S., Saito, K. et al. Pseudoangiomatous stromal hyperplasia (PASH) of the mammary gland: Report of a case. Surg Today 38, 340–343 (2008). https://doi.org/10.1007/s00595-007-3613-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00595-007-3613-6