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Peritoneal Recurrence of Gastric Cancer with Mucin Phenotype 12 Years After Curative Resection: Report of a Case

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Abstract

We report a case of peritoneal recurrence of gastric cancer in a 58-year-old man, 12 years after curative surgery. Urinary wall thickness was seen on follow-up computed tomography and magnetic resonance imaging scans. We performed total nephroureterectomy and cystectomy for urinary tract cancers, but histological examination of the resected specimen revealed poorly differentiated adenocarcinoma with severe fibrosis, resembling the gastric cancer resected 12 years earlier. Immunohistological examination revealed human gastric mucin (45M1) and intestinal mucin (MUC2) phenotype in both the original gastric cancers and the urinary tract cancers. Thus, we concluded that the second cancer was a peritoneal recurrence of gastric cancer with gastric and intestinal mucin phenotypes. Although peritoneal recurrence so many years after curative gastrectomy is rare, careful long-term follow-up should be done for all patients undergoing surgery for gastric cancer with mucin phenotype.

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References

  1. F Roviello D Marrelli G de Manzoni P Morgagni A Di Leo L Saragoni (2003) ArticleTitleProspective study of peritoneal recurrence after curative surgery for gastric cancer Br J Surg 90 IssueID9 1113–9 Occurrence Handle12945079 Occurrence Handle10.1002/bjs.4164 Occurrence Handle1:STN:280:DC%2BD3svgsFemsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  2. M Nishi Y Omori K Miwa (1995) Japanese classification of gastric carcinoma. 1st English ed Kanehara Tokyo 6–15

    Google Scholar 

  3. CH Yoo SH Noh DW Shin SH Choi JS Min (2000) ArticleTitleRecurrence following curative resection for gastric carcinoma Br J Surg 87 236–42 Occurrence Handle10671934 Occurrence Handle10.1046/j.1365-2168.2000.01360.x Occurrence Handle1:STN:280:DC%2BD3c7jslymsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  4. Y Maehara S Hasuda T Koga E Tokunaga Y Kakeji K Sugimach (2000) ArticleTitlePostoperative outcome and sites of recurrence in patients following curative resection of gastric cancer Br J Surg 87 353–7 Occurrence Handle10718807 Occurrence Handle10.1046/j.1365-2168.2000.01358.x Occurrence Handle1:STN:280:DC%2BD3c7otlCjtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  5. T Iwanaga H Koyama H Furukawa H Taniguchi A Wada R Tateishi (1978) ArticleTitleMechanisms of late recurrence after radical surgery for gastric carcinoma Am J Surg 135 IssueID5 637–40 Occurrence Handle646037 Occurrence Handle10.1016/0002-9610(78)90126-5 Occurrence Handle1:STN:280:CSeC28zpsFc%3D

    Article  PubMed  CAS  Google Scholar 

  6. E Mochiki H Kuwano H Katoh H Taniguchi A Wada R Tateishi (2004) ArticleTitleEvaluation of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography for gastric cancer World J Surg 28 IssueID3 247–53 Occurrence Handle14961197 Occurrence Handle10.1007/s00268-003-7191-5

    Article  PubMed  Google Scholar 

  7. E Silva A Teixeira L David F Carneiro CA Reis J Sobrinho-Simões et al. (2002) ArticleTitleMucins as key molecules for the classification of intestinal metaplasia of the stomach Virchows Arch 440 311–7 Occurrence Handle11889603 Occurrence Handle10.1007/s004280100531 Occurrence Handle1:CAS:528:DC%2BD38Xhsleksbw%3D

    Article  PubMed  CAS  Google Scholar 

  8. YS Kim JR Gum SuffixJr (1995) ArticleTitleDiversity of mucin genes, structure, function, and expression Gastroenterology 109 999–1023 Occurrence Handle7657131 Occurrence Handle10.1016/0016-5085(95)90412-3 Occurrence Handle1:STN:280:ByqA1crps1Y%3D

    Article  PubMed  CAS  Google Scholar 

  9. J Bara R Gautier N Daher H Zaghouani C Decaens (1986) ArticleTitleMonoclonal antibodies against oncofetal mucin M1 antigens associated with precancerous colonic mucoase Cancer Res 46 3983–9 Occurrence Handle3524800 Occurrence Handle1:CAS:528:DyaL28XltFehsbw%3D

    PubMed  CAS  Google Scholar 

  10. J Bara R Gautier P Mouradian C Decaens N Daher (1991) ArticleTitleOncofetal mucin M1 epitope family: Characterization and expression during colonic carcinogenesis Int J Cancer 47 304–10 Occurrence Handle1988372 Occurrence Handle10.1002/ijc.2910470222 Occurrence Handle1:CAS:528:DyaK3MXhvVent7c%3D

    Article  PubMed  CAS  Google Scholar 

  11. CA Reis L David P Correa F Carnerio C de Bolos E Garcia et al. (1999) ArticleTitleIntestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression Cancer Res 59 1003–7 Occurrence Handle10070955 Occurrence Handle1:CAS:528:DyaK1MXhslemtLc%3D

    PubMed  CAS  Google Scholar 

  12. Y Tajima T Shimoda Y Nakanishi (2001) ArticleTitleGastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: Immunohistochemical analysis of 136 lesions Oncology 61 212–20 Occurrence Handle11574777 Occurrence Handle10.1159/000055377 Occurrence Handle1:STN:280:DC%2BD3MrivVKntg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  13. Y Ajioka H Watanabe JR Jass (1997) ArticleTitleMUC1 and MUC2 mucin in flat and polypoid colorectal adenomas J Clin Pathol 50 417–21 Occurrence Handle9215126 Occurrence Handle1:STN:280:ByiA2MjpsVE%3D

    PubMed  CAS  Google Scholar 

  14. KM Tytgat HA Buller FJ Opdam YS Kim AW Einerhand J Dekker (1994) ArticleTitleBiosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin Gastroenterology 107 1352–63 Occurrence Handle7926500 Occurrence Handle1:CAS:528:DyaK2MXitlGmsLg%3D

    PubMed  CAS  Google Scholar 

  15. A Saito T Shimoda Y Nakanishi A Ochiai G Toda (2001) ArticleTitleHistologic heterogeneity and mucin phenotypic expression in early gastric cancer Pathol Int 51 165–71 Occurrence Handle11328531 Occurrence Handle10.1046/j.1440-1827.2001.01179.x Occurrence Handle1:STN:280:DC%2BD3MzhsVGiuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  16. A Yoshikawa K Inada Ki T Yamachika N Shimizu M Kaminishi M Tatematsu (1998) ArticleTitlePhenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression Gastric Cancer 1 134–41 Occurrence Handle11957057 Occurrence Handle10.1007/s101200050007

    Article  PubMed  Google Scholar 

  17. R Aihara E Mochiki Y Kamiyama H Kamimura T Asao H Kuwano (2004) ArticleTitleMucin phenotypic expression in early signet ring cell carcinoma of the stomach: its relationship with the clinicopathologic factors Dig Dis Sci 49 IssueID3 417–24 Occurrence Handle15139491 Occurrence Handle10.1023/B:DDAS.0000020496.98711.14 Occurrence Handle1:CAS:528:DC%2BD2cXitlGkt7Y%3D

    Article  PubMed  CAS  Google Scholar 

  18. R Aihara E Mochiki T Nakabayashi K Akazawa T Asao H Kuwano (2005) ArticleTitleClinical significance of mucin phenotype, beta-catenin and matrix metalloproteinase 7 in early undifferentiated gastric carcinoma Br J Surg 92 IssueID4 454–62 Occurrence Handle15609380 Occurrence Handle10.1002/bjs.4868 Occurrence Handle1:CAS:528:DC%2BD2MXktFGgtr4%3D

    Article  PubMed  CAS  Google Scholar 

  19. D Marrelli F Roviello G de Manzoni P Morgagni A Di Leo L Saragoni et al. (2002) ArticleTitleDifferent patterns of recurrence in gastric cancer depending on Lauren's histological type: longitudinal study World J Surg 26 IssueID9 1160–5 Occurrence Handle12209247 Occurrence Handle10.1007/s00268-002-6344-2

    Article  PubMed  Google Scholar 

  20. DH Roukos M Lorenz K Karakostas P Paraschou C Batsis AM Kappas (2001) ArticleTitlePathological serosa and node-based classification accurately predicts gastric cancer recurrence risk and outcome, and determines potential and limitation of a Japanese-style extensive surgery for Western patients: a prospective with quality control 10-year follow-up study Br J Cancer 84 IssueID12 1602–9 Occurrence Handle11401312 Occurrence Handle10.1054/bjoc.2001.1720 Occurrence Handle1:STN:280:DC%2BD3MzjsVSgtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  21. K Maruyama K Okabayashi T Kinoshita (1987) ArticleTitleProgress in gastric cancer surgery in Japan and its limits of radicality World J Surg 11 IssueID4 418–25 Occurrence Handle3630186 Occurrence Handle10.1007/BF01655804 Occurrence Handle1:STN:280:BiiA387kt1w%3D

    Article  PubMed  CAS  Google Scholar 

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Aihara, R., Mochiki, E., Ohotake, S. et al. Peritoneal Recurrence of Gastric Cancer with Mucin Phenotype 12 Years After Curative Resection: Report of a Case. Surg Today 37, 325–329 (2007). https://doi.org/10.1007/s00595-006-3392-5

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  • DOI: https://doi.org/10.1007/s00595-006-3392-5

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