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Mucinous Carcinoma of the Duodenum Associated with Hereditary Nonpolyposis Colorectal Cancer: Report of a Case

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Abstract

We herein report a rare case of primary mucinous carcinoma of the duodenum associated with hereditary nonpolyposis colorectal cancer (HNPCC). A 50-year-old man known to have HNPCC based on the Amsterdam criteria I was admitted because of the presence of a duodenal tumor. Duodenoscopy revealed an ulcerated tumor in the posterior wall of the second portion of the duodenum and the malignancy was confirmed by a biopsy. He underwent a pylorus-preserving pancreaticoduodenectomy with a regional lymph node dissection. The histological diagnosis was mucinous carcinoma of the duodenum with lymph node metastasis. High-frequency microsatellite instability (MSI-H) was identified in both the colon and a duodenal specimen based on a microsatellite assay. A germline mutation in the hMSH2 gene was also identified. Even though extracolonic malignancies are associated with HNPCC, duodenal cancer is nevertheless very rare, and only two cases have been reported over the past 20 years. The present case is therefore only the third such case and the patient is herein described with a brief review of the literature.

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References

  1. M Aarnio JP Mecklin LA Aaltonen M Nystrom-Lahti HJ Jarvinen (1995) ArticleTitleLife-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome Int J Cancer 64 430–33 Occurrence Handle8550246 Occurrence Handle1:STN:280:BymC2cvotVQ%3D

    PubMed  CAS  Google Scholar 

  2. HF Vasen JT Wijnen FH Menko JH Kleibeuker BG Taal G Griffioen et al. (1996) ArticleTitleCancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis Gastroenterology 110 1020–27 Occurrence Handle8612988 Occurrence Handle1:STN:280:BymC1czhtlI%3D Occurrence Handle10.1053/gast.1996.v110.pm8612988

    Article  PubMed  CAS  Google Scholar 

  3. J Kleinerman K Yardumian HT Tamaki (1950) ArticleTitlePrimary carcinoma of the duodenum Ann Intern Med 32 451–65

    Google Scholar 

  4. VM Iovine N Tsabgaris (1961) ArticleTitlePrimary carcinoma of the duodenum Am Surg 27 744–50

    Google Scholar 

  5. A Alwmark A Andersson A Lasson (1980) ArticleTitlePrimary carcinoma of the duodenum Ann Surg 191 13–8 Occurrence Handle7352773 Occurrence Handle1:STN:280:Bi%2BC3cfisFM%3D

    PubMed  CAS  Google Scholar 

  6. RP Kerremans J Lerut FM Penninckx (1979) ArticleTitlePrimary malignant duodenal tumors Ann Surg 190 179–82 Occurrence Handle464691 Occurrence Handle1:STN:280:CSaB3s%2Fks1A%3D Occurrence Handle10.1097/00000658-197908000-00010

    Article  PubMed  CAS  Google Scholar 

  7. NM Ryder CY Ko OJ Hines B Gloor HA Reber (2000) ArticleTitlePrimary duodenal adenocarcinoma: a 40-year experience Arch Surg 135 1070–4 Occurrence Handle10982512 Occurrence Handle1:STN:280:DC%2BD3cvmtF2ktw%3D%3D Occurrence Handle10.1001/archsurg.135.9.1070

    Article  PubMed  CAS  Google Scholar 

  8. CR Boland SN Thibodeau SR Hamilton D Sidransky JR Eshleman RW Burt et al. (1998) ArticleTitleA National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer Cancer Res 58 5248–57 Occurrence Handle9823339 Occurrence Handle1:CAS:528:DyaK1cXnsFSmtbk%3D

    PubMed  CAS  Google Scholar 

  9. AS Warthin (1913) ArticleTitleHereditary with reference to carcinoma as shown by the study of the cases examined in a pathological laboratory of the University of Michigan, 1895–1913 Arch Intern Med 12 546–55

    Google Scholar 

  10. HF Vasen JP Mecklin PM Khan HT Lynch (1991) ArticleTitleThe International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) Dis Colon Rectum 34 424–5 Occurrence Handle2022152 Occurrence Handle1:STN:280:By6B3MrpslU%3D Occurrence Handle10.1007/BF02053699

    Article  PubMed  CAS  Google Scholar 

  11. JP Mecklin M Pontz de Leon (1994) ArticleTitleEpidemiology of HNPCC Anticancer Res 14 1625–9 Occurrence Handle7979197 Occurrence Handle1:STN:280:ByqD28bptFE%3D

    PubMed  CAS  Google Scholar 

  12. DA Lawes SB SenGupta PB Boulos (2002) ArticleTitlePathogenesis and clinical management of hereditary non-polyposis colorectal cancer Br J Surg 89 1357–69 Occurrence Handle12390374 Occurrence Handle1:STN:280:DC%2BD38njt1agtg%3D%3D Occurrence Handle10.1046/j.1365-2168.2002.02290.x

    Article  PubMed  CAS  Google Scholar 

  13. DC Chang AK Rustgi (2003) ArticleTitleThe hereditary nonpolyposis colorectal cancer syndrome. Genetics and clinical implications Ann Intern Med 138 560–70

    Google Scholar 

  14. HF Vasen P Watson JP Mecklin HT Lynch (1999) ArticleTitleNew clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC Gastroenterology 116 1453–6 Occurrence Handle10348829 Occurrence Handle1:STN:280:DyaK1M3nvVamuw%3D%3D Occurrence Handle10.1016/S0016-5085(99)70510-X

    Article  PubMed  CAS  Google Scholar 

  15. T Arai T Murata M Sawabe K Takubo Y Esaki (1999) ArticleTitlePrimary adenocarcinoma of the duodenum in the elderly: clinicopathological and immunohistochemical study of 17 cases Pathol Int 49 23–9 Occurrence Handle10227721 Occurrence Handle1:STN:280:DyaK1M3kt1arsg%3D%3D Occurrence Handle10.1046/j.1440-1827.1999.00820.x

    Article  PubMed  CAS  Google Scholar 

  16. G Sugawara A Yamaguchi M Isogai T Harada Y Kaneoka M Suzuki et al. (2001) ArticleTitleA clinicopathological study on primary carcinoma of the duodenum (in Japanese with English abstract) Jpn J Gastroenterol Surg 34 1283–8

    Google Scholar 

  17. MA Rodriguez-Bigas HF Vasen HT Lynch P Watson T Myrhoj HJ Jarvinen et al. (1998) ArticleTitleCharacteristics of small bowel carcinoma in hereditary nonpolyposis colorectal cancer Cancer 83 240–4 Occurrence Handle9669805 Occurrence Handle1:STN:280:DyaK1czjt1Clug%3D%3D Occurrence Handle10.1002/(SICI)1097-0142(19980715)83:2<240::AID-CNCR6>3.0.CO;2-U

    Article  PubMed  CAS  Google Scholar 

  18. JR Jass TC Smyrk SM Stewart MR Lane SJ Lanspa HT Lynch (1994) ArticleTitlePathology of hereditary nonpolyposis colorectal cancer Anticancer Res 14 1631–4 Occurrence Handle7979198 Occurrence Handle1:STN:280:ByqD28bptFI%3D

    PubMed  CAS  Google Scholar 

  19. DM Graham HD Appelman (1990) ArticleTitleCrohn's-like lymphoid reaction and colorectal carcinoma: a potential histologic prognosticator Mod Pathol 3 332–5 Occurrence Handle2362940 Occurrence Handle1:STN:280:By%2BA3c7nsFQ%3D

    PubMed  CAS  Google Scholar 

  20. MA Rodriguez-Bigas CR Boland SR Hamilton DE Henson JR Jass PM Khan et al. (1997) ArticleTitleA National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines J Natl Cancer Inst 89 1758–62 Occurrence Handle9392616 Occurrence Handle1:STN:280:DyaK1c%2Flt1Gjuw%3D%3D Occurrence Handle10.1093/jnci/89.23.1758

    Article  PubMed  CAS  Google Scholar 

  21. P Watson HT Lynch (1993) ArticleTitleExtracolonic cancer in hereditary nonpolyposis colorectal cancer Cancer 71 677–85 Occurrence Handle8431847 Occurrence Handle1:STN:280:ByyC287itlc%3D Occurrence Handle10.1002/1097-0142(19930201)71:3<677::AID-CNCR2820710305>3.0.CO;2-#

    Article  PubMed  CAS  Google Scholar 

  22. HF Vasen JP Mecklin P Watson J Utsunomiya L Bertario P Lynch et al. (1993) ArticleTitleSurveillance in hereditary nonpolyposis colorectal cancer: an international cooperative study of 165 families. The International Collaborative Group on HNPCC Dis Colon Rectum 36 1–4 Occurrence Handle8416772 Occurrence Handle1:STN:280:ByyC3crntlc%3D Occurrence Handle10.1007/BF02050292

    Article  PubMed  CAS  Google Scholar 

  23. K Mitsuya M Shibuya M Matsuoka (1987) ArticleTitleA case of triple cancer including early duodenal cancer (in Japanese with English abstract) Prog Dig Endosc 31 374–7

    Google Scholar 

  24. K Hanazaki J Kusama T Katsuyama (1988) ArticleTitleA case of early carcinoma of the duodenum associated with advanced carcinoma of the descending colon (in Japanese with English abstract) Endosc forum Dig Dis 4 134–40

    Google Scholar 

  25. H Yanagie H Imai T Tani M Ogata (1990) ArticleTitleA case of primary early duodenal cancer (in Japanese with English abstract) Gan No Rinsho (Jpn J Cancer Clinics) 36 2063–6 Occurrence Handle1:STN:280:By6D3sbpsVQ%3D

    CAS  Google Scholar 

  26. R Yoshida H Takada K Nakagawa et al. (1995) ArticleTitleA case of triple cancer including duodenal cancer (in Japanese with English abstract) Gan No Rinsho (Jpn J Cancer Clinics) 41 2063–6

    Google Scholar 

  27. K Konishi H Tajiri T Fujii N Boku A Ohtu S Yoshida et al. (1998) ArticleTitleHereditary nonpolyposis colorectal cancer associated with duodenal carcinoma: a case report Jpn J Clin Oncol 28 289–93 Occurrence Handle9657018 Occurrence Handle1:STN:280:DyaK1czitFagtQ%3D%3D Occurrence Handle10.1093/jjco/28.4.289

    Article  PubMed  CAS  Google Scholar 

  28. N Miyao H Serizawa H Takahashi et al. (1998) ArticleTitleA case of multiple hepatoid adenocarcinoma in the duodenum, ascending, transverse colon and mediastinum (in Japanese with English abstract) Prog Dig Endosc 52 74–7

    Google Scholar 

  29. Y Yagi A Seshimo M Mitsuhashi T Aratake M Yamatake R Hujita et al. (2000) ArticleTitleA case of synchronous triple cancers of the stomach, colon and duodenum which was associated with EBV (in Japanese with English abstract) Nihon Shokaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 30 735–8

    Google Scholar 

  30. M Fukunaga N Tomita K Yamazaki Y Takatsuka O Imamoto H Osato et al. (2001) ArticleTitleA case of HNPCC with five metachronous primary cancers in colon, lung and duodenum, in which germline mutation of neither hMLH1 nor Hmsh2 gene could be detected (in Japanese with English abstract) Kazokuseisyuyo (J Fam Tumor) 1 66–7

    Google Scholar 

  31. M Mukai H Makuuchi S Mukohyama Y Oida S Himeno T Nishi et al. (2001) ArticleTitleQuintuple carcinomas with metachronous triple cancer of the esophagus, kidney, and colonic conduit following synchronous double cancer of the stomach and duodenum Oncol Rep 8 111–4 Occurrence Handle11115580 Occurrence Handle1:STN:280:DC%2BD3M7ivFOqug%3D%3D

    PubMed  CAS  Google Scholar 

  32. H Sawai M Tanaka H Funahashi M Yamamoto Y Okada H Takeyama et al. (2003) ArticleTitleMultiple primary cancers of the duodenum and sigmoid colon: report of two cases Dig Dis Sci 48 1268–72 Occurrence Handle12870782 Occurrence Handle10.1023/A:1024194706710

    Article  PubMed  Google Scholar 

  33. S Shibasaki Y Sato M Kondo S Takahashi T Shinohara S Todo (2004) ArticleTitleA case of quadruple cancer including multiple remnant gastric cancer (in Japanese with English abstract) Nippon Rinsho Geka Gakkai Zasshi 65 544–8

    Google Scholar 

  34. Y Tanaka M Kuroda M Yokoi H Harada S Yoshitani H Saito et al. (2004) ArticleTitleA long-term surviving case of metachronous double carcinoma in the duodenum and sigmoid colon J Kanazawa Med Univ 29 115–9

    Google Scholar 

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Authors and Affiliations

  1. Second Department of Surgery, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya-shi, Hyogo, 663-8501, Japan

    Toshihiko Yagyu

  2. Department of Surgery, Meiwa General Hospital, Hyogo, Japan

    Tsukasa Aihara

  3. Department of Surgery, Japan Self Defense Force Central Hospital, Tokyo, Japan

    Michinori Murayama & Kazuo Hase

  4. Department of Surgery, Japan Self-Defense Force Hanshin Hospital, Hyogo, Japan

    Shoichi Kikuchi & Eisyu Nakamura

  5. First Department of Surgery, National Defense Medical College, Saitama, Japan

    Kazuo Hatsuse & Hidetaka Mochizuki

  6. Laboratory of Hereditary Tumor, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan

    Kazuo Tamura

Authors
  1. Toshihiko Yagyu
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  2. Tsukasa Aihara
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  3. Michinori Murayama
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  9. Hidetaka Mochizuki
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Yagyu, T., Aihara, T., Murayama, M. et al. Mucinous Carcinoma of the Duodenum Associated with Hereditary Nonpolyposis Colorectal Cancer: Report of a Case. Surg Today 36, 1129–1132 (2006). https://doi.org/10.1007/s00595-006-3321-7

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  • DOI: https://doi.org/10.1007/s00595-006-3321-7

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