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Large Cell Neuroendocrine Carcinoma of the Ampulla of Vater: Report of a Case

Surgery Today volume 36, pages 1032–1035 (2006)Cite this article

Abstract

Large cell neuroendocrine carcinoma in the ampulla of Vater is rare and very different from the common ampullary adenocarcinoma. A 59-year-old man was admitted with obstructive jaundice. Gastroendoscopy showed a swollen ampulla of Vater and pathological examination of an ampullary biopsy revealed findings of a carcinoid tumor. After endoscopic biliary drainage, he underwent pancreaticoduodenectomy. A diagnosis of large cell neuroendocrine carcinoma was confirmed by immunohistochemical examination of the resected specimen. Despite adjuvant chemotherapy with cyclophosphamide and cisplatin, liver and peritoneal metastasis developed within 5 months and he survived for only 10 months after the operation. Thus, further investigations are needed to find a more effective postoperative adjuvant chemotherapy agent to treat patients with this aggressive tumor.

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Authors and Affiliations

  1. Departments of Surgery, Taichung Veterans General Hospital, Section 3, 160 Chung-Kang Road, Taichung, Taiwan

    So-Sen Huang, Shao-Bin Cheng, Dah-Cherng Yeh, Cheng-Chung Wu, Tse-Jia Liu & Fang-Ku P'eng

  2. Departments of Pathology, Taichung Veterans General Hospital, Section 3, 160 Chung-Kang Road, Taichung, Taiwan

    Yee-Jee Jan

  3. Department of Surgery, Faculty of Medicine, Chung-Shan Medical University, Taichung, Taiwan

    Shao-Bin Cheng, Dah-Cherng Yeh & Cheng-Chung Wu

  4. Department of Surgery, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan

    Cheng-Chung Wu, Tse-Jia Liu & Fang-Ku P'eng

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  1. So-Sen Huang
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Huang, SS., Jan, YJ., Cheng, SB. et al. Large Cell Neuroendocrine Carcinoma of the Ampulla of Vater: Report of a Case. Surg Today 36, 1032–1035 (2006). https://doi.org/10.1007/s00595-006-3285-7

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  • DOI: https://doi.org/10.1007/s00595-006-3285-7

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