Abstract
We report a rare case of a solitary metachronous metastasis of renal clear cell carcinoma (RCC) presenting as a thyroid tumor 19 years after a nephrectomy. Our search of the English-language literature found only sporadic reports of late RCC metastases to the thyroid. Fine-needle aspiration biopsy of the thyroid tumor was not accompanied with thyroglobulin (Tg) staining, leading us to initially suspect a primary follicular thyroid carcinoma. The patient, a 77-year-old man, underwent a total thyroidectomy with modified neck dissection. Histological examination confirmed the tumor to be RCC metastasis, and immunohistochemical analysis revealed that both Tg and thyroid transcription factor-1 (TTF-1) were negative in the tumor cells. Thus, the possibility of late RCC metastasis to the thyroid should be considered, even in a patient with a remote history. Furthermore, TTF-1 is useful for identifying thyroid metastatic carcinomas.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wada, N., Hirakawa, S., Rino, Y. et al. Solitary Metachronous Metastasis to the Thyroid from Renal Clear Cell Carcinoma 19 Years After Nephrectomy: Report of a Case. Surg Today 35, 483–487 (2005). https://doi.org/10.1007/s00595-004-2953-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00595-004-2953-8