Abstract.
Parameters related to oxidative stress were studied in rats divided into 4 groups: streptozotocin-induced diabetic rats (n=10), diabetic rats who received a single dose of a basic fraction of Ficus carica extract (n=14), diabetic rats who received a single dose of a chloroform fraction of the extract (n=10), and normal rats (n=10). Compared to normal animals, the diabetic animals presented significantly higher values for erythrocyte catalase normalized to haemoglobin levels (1.5±0.15 vs. 0.96±0.18 μg/mg) and for plasma vitamin E (73.4±43.9 vs. 12.0±1.6 mg/l), monounsaturated fatty acids (0.219±0.118 vs. 0.067±0.014 mg/ml), polyunsaturated fatty acids (PUFA, 0.567±0.293 vs. 0.175±0.040 mg/ml), saturated fatty acids (0.779±0.262 vs. 0.401±0.055 mg/ml), and linoleic acid (0.202±0.086 vs. 0.106 ±0.014 mg/ml). Both Ficus carica fractions tended to normalize the values of the diabetic animals' fatty acids and plasma vitamin E values. On studying the ratios of vitamins E and A to PUFA (129.4±77.5 diabetic and 68.8±9.1 μg/mg normal; 37.5±20.8 vs. 108.0±43.6 μg/mg) and to C18:2 (259.9±65.8 vs. 161.0±21.3 μg/mg; 68.3±37.9 vs. 252.7±102.1 μg/mg), we found statistically significant differences as a function of diabetes, with the vitamin E/C18:2 ratio being normalized by the administration of the chloroform fraction (to 152.1±80.3 μg/mg) and the vitamin A/C18:2 ratio being raised relative to the untreated diabetic rats by the administration of the basic fraction (91.9±14.5 μg/mg). Our work confirms that antioxidant status is affected in the diabetes syndrome, and that Ficus carica extracts tend to normalize it.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: September 2000 / Accepted in revised form: September 2002
Correspondence to M.D. Torres
Rights and permissions
About this article
Cite this article
Pèrez, C., Canal, J. & Torres, M. Experimental diabetes treated with ficus carica extract: effect on oxidative stress parameters. Acta Diabetol 40, 3–8 (2003). https://doi.org/10.1007/s005920300001
Issue Date:
DOI: https://doi.org/10.1007/s005920300001