Anti-single-stranded(ss)DNA antibodies were searched for by enzyme-linked immunosorbent assay (ELISA) in the serum of 202 outpatients with non-insulin-dependent diabetes mellitus and 135 healthy subjects to investigate their prevalence in the serum of patients with type 2 diabetes and their relationship with the presence of vascular complications. Of the 202 patients 128 had vascular complications. Anti-ssDNA antibodies were observed to be significantly more frequent in the serum of patients with vascular complications (33.6%) and in particular in patients with overt nephropathy (50%) than in patients without complications (6.7%) or controls (6.7%). Anti-ssDNA antibodies have been previously described in patients with type 1 diabetes before clinical evidence of vascular disease, and their cross-reactivity with a variety of anionic biological molecules or cells, i.e. platelets and endothelial cells, assessed. It seems not unreasonable that these autoantibodies detected in patients with type 2 diabetes could be of importance in the pathogenesis or progression of angiopathy.
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Received: 19 March 1996 / Accepted in revised form: 9 October 1996
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Giardina, E., Triolo, G., Accardo-Palumbo, A. et al. Anti-single-stranded DNA antibody in the sera of patients with type 2 diabetes mellitus . Acta Diabetologica 34, 39–41 (1997). https://doi.org/10.1007/s005920050063
- Key words Anti-single-stranded DNA antibodies
- Type 2 diabetes
- Vascular complications