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Data availability
The datasets generated during and/or analysed during the current study are not publicly available but are available from the corresponding authors on reasonable request.
Abbreviations
- ACMG/AMP:
-
The American College of Medical Genetics and Genomics and the Association for Molecular Pathology
- DKA:
-
Diabetic ketoacidosis
- DM:
-
Diabetes mellitus
- MODY:
-
Maturity-onset diabetes of the young
- NGS:
-
Next-generation sequencing
- PNDM:
-
Permanent neonatal diabetes mellitus
- VUS:
-
Variants of uncertain significance
References
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Funding
This work was supported by the Italian Ministry of Health (Ricerca Corrente 2018–2021 to S. P.).
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Contributions
SP and FB designed the study, interpreted data and wrote the manuscript. FA performed statistical analyses. LM,F Alberico., AD, GCM, RDP and MC performed genetic analyses, FA, PP, SM, GP, SDC and VT recruited and characterized patients with type 2 diabetes. OL, VT and FB recruited and characterized patients with suspected monogenic diabetes. All authors were involved in the critical revision of the manuscript and approved the final version of this article. SP and FB are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
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The authors declared that they have no conflict of interest.
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Study protocols and informed consent procedures were approved by the local Institutional Ethic Committees and all participants gave written consent. This study was carried out in accordance with the Declaration of Helsinki, as revised in 2000.
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All patients consented to genetic testing.
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Prudente, S., Andreozzi, F., Mercuri, L. et al. Contribution of ONECUT1 variants to different forms of non-autoimmune diabetes mellitus in Italian patients. Acta Diabetol 59, 1113–1116 (2022). https://doi.org/10.1007/s00592-022-01889-w
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DOI: https://doi.org/10.1007/s00592-022-01889-w