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Evaluation of left ventricular systolic and diastolic function in subjects with prediabetes and diabetes using cardiovascular magnetic resonance-feature tracking

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Abstract

Aims

The aim of this study was to evaluate alterations in left ventricular (LV) systolic and diastolic function in subjects with prediabetes and diabetes using cardiovascular magnetic resonance-feature tracking (CMR- FT).

Methods

We included 35 subjects with prediabetes, 30 subjects with diabetes, and 33 healthy controls of similar age and sex distributions who underwent CMR examination. LV global radial, circumferential, and longitudinal strain (GRS, GCS, and GLS), peak systolic strain rate (PSSR), and peak diastolic strain rate (PDSR) were measured and compared among the three groups. Pearson’s correlation and linear regression analyses were applied for statistical analyses.

Results

Subjects with prediabetes and diabetes had a significantly lower GLS than healthy controls, but there were no significant differences in ejection fraction (EF), GRS, GCS, or global radial, circumferential and longitudinal PSSR among the three groups. Global radial, circumferential, and longitudinal PDSR in patients with diabetes were all significantly lower than those in the healthy controls. Compared to subjects with prediabetes, patients with diabetes had a significantly lower global circumferential PDSR. Global longitudinal PDSR in subjects with prediabetes was significantly lower than that in healthy controls. Multivariable linear regression analyses demonstrated that elevated HbA1c levels were independently associated with decreased global circumferential and longitudinal PDSR (β = −0.203, p = 0.023; β = −0.207, p = 0.040, respectively).

Conclusions

CMR-FT has potential value to evaluate early alterations in LV systolic and diastolic function in subjects with prediabetes and diabetes. Elevated HbA1c levels were independently associated with impaired LV diastolic function in the general population free of overt cardiovascular diseases.

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Availability of data and material

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors thank all the staff of Zhouxin Medical Imaging and Health Screening Center, Xiamen, China for their help in obtaining images and data.

Funding

Not applicable.

Author information

Author notes

  1. Shanshan Zhou and Zheng Zhang contributed equally to this work.

Authors and Affiliations

  1. Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China

    Shanshan Zhou, Zhen Zhang, Yiyuan Gao, Gengxiao Li, Mingwu Lou & Kuncheng Li

  2. Department of Radiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Zheng Zhang

  3. Post-Doctoral Research Center, Longgang Central Hospital of Shenzhen, Guangdong, China

    Zhen Zhang & Mingwu Lou

  4. Zhouxin Medical Imaging and Health Screening Center, Xiamen, Fujian, China

    Zhiwei Zhao, Jun Zhao, Kuncheng Li & Gerald M. Pohost

  5. Department of Radiology, Xuanwu Hospital, Capital Medical University, No 45 Changchun Street, Xicheng District, Beijing, 100053, China

    Kuncheng Li

  6. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Gerald M. Pohost

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  1. Shanshan Zhou
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Correspondence to Kuncheng Li.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This retrospective study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Chinese Ethics Committee approved this study with a waiver of written informed consent (ChiECRCT20190198). Project start date: October 10, 2019.

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The study was retrospectively registered and approved by the Chinese Ethics Committee (ChiECRCT20190198). Project start date: October 10, 2019.

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Cite this article

Zhou, S., Zhang, Z., Zhang, Z. et al. Evaluation of left ventricular systolic and diastolic function in subjects with prediabetes and diabetes using cardiovascular magnetic resonance-feature tracking. Acta Diabetol 59, 491–499 (2022). https://doi.org/10.1007/s00592-021-01822-7

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  • DOI: https://doi.org/10.1007/s00592-021-01822-7

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