Acta Diabetologica

, Volume 55, Issue 7, pp 759–761 | Cite as

Empagliflozin, metformin and insulin degludec, during pregnancy: a case report

  • G. Formoso
  • F. Ginestra
  • G. Di Dalmazi
  • A. Consoli
Case Report


Pregnancy Diabetes Therapy Metformin Empagliflozin Degludec 


Compliance with ethical standards

Conflict of interest

A.C. has received speaker fees and/or consulting honoraria from Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Merck Sharp & Dohme, Novartis, Novo Nordisk, Roche Diagnostics, Sanofi-Aventis, Takeda and has received research grant support from Eli Lilly and Novo Nordisk. G.F. has received speaker fees from Eli Lilly, Merck Sharp & Dohme, Menarini Diagnostics and Servier. F.G. and G.D.D. have received nothing.

Ethical approval

The study was in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from the patient included in the case report.


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    Marso SP, McGuire DK, Zinman B et al (2017) Efficacy and safety of degludec versus glargine in type 2 diabetes. N Engl J Med 377:723–732. CrossRefPubMedPubMedCentralGoogle Scholar
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    Simmons D (2010) Metformin treatment for TYPE 2 diabetes in pregnancy? Best Pract Res Clin Endocrinol Metab 24:625–634. CrossRefPubMedGoogle Scholar
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    Zinman B, Marso SP, Poulter NR et al (2018) Day-to-day fasting glycaemic variability in DEVOTE: associations with severe hypoglycaemia and cardiovascular outcomes (DEVOTE 2). Diabetologia 61:48–57. CrossRefPubMedGoogle Scholar
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    Milluzzo A, Tumminia A, Scalisi NM, Frittitta L, Vigneri R, Sciacca L (2017) Insulin degludec in the first trimester of pregnancy: report of two cases. J Diabetes Investig. PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medicine and Aging Sciences, Aging and Translational Medicine Research Center (CeSI-Met)G. d’Annunzio UniversityChietiItaly

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