Skip to main content
SpringerLink
Log in

Switching from Glargine to Degludec is not associated with an overt change in glucose control in a cohort of patients with type 1 diabetes: a CGM analysis

  • Short Communication
  • Published:
Acta Diabetologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

CGM:

Continuous glucose monitoring

NPH:

Neutral protamine hagedorn

T1DM:

Type 1 diabetes mellitus

T2DM:

Type 2 diabetes mellitus

AUC:

Area under curve

CONGA:

Continuous overlapping net glycemic action

BGR:

Blood glucose rate

LBGI:

Low Blood Glucose Index

HBGI:

High Blood Glucose Index

MAGE:

Mean amplitude glycemic excursion

References

  1. Yamamoto C, Miyoshi H, Fujiwara Y et al (2016) Degludec is superior to Glargine in terms of daily glycemic variability in people with type 1 diabetes mellitus. Endocr J 63(1):53–60

    Article  PubMed  CAS  Google Scholar 

  2. Siegmund T, Tentolouris N, Knudsen ST et al (2017) A European multicentre retrospective non interventional study (EU-TREAT) of the effectiveness of insulin Degludec after switching basal insulin in a population with type 1 or type 2 diabetes. Diabetes Obes Metab. https://doi.org/10.1111/dom.13149

    Article  PubMed  PubMed Central  Google Scholar 

  3. Lane W, Bailey TS, Gerety G et al (2017) Effect of insulin Degludec vs insulin Glargine U100 on hypoglycemia in patients with type 1 diabetes: the SWITCH 1 randomized clinical trial. JAMA 318(1):33–44

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Galasso S, Facchinetti A, Bonora BM et al (2016) Switching from twice-daily Glargine or detemir to once-daily Degludec improves glucose control in type 1 diabetes. An observational study. Nutr Metab Cardiovasc Dis 26(12):1112–1119

    Article  PubMed  CAS  Google Scholar 

  5. Tosaka Y, Kanazawa A, Ikeda F et al (2015) Switching from twice-daily basal insulin injections to once-daily insulin Degludec injection for basal-bolus insulin regimen in japanese patients with type 1 diabetes: a pilot study. Int J Endocrinol 2015:176261

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine (DIMI), University of Genova and Ospedale Policlinico San Martino, viale Benedetto XV 6, 16132, Genoa, Italy

    Laura Affinito Bonabello, Davide Maggi & Renzo Cordera

  2. Department of Informatics, Bioengineering, Robotics and Systems Engineering, University of Genova, Via Dodecaneso 35, Genoa, Italy

    Samuele Fiorini & Veronica Tozzo

Authors
  1. Laura Affinito Bonabello
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Davide Maggi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Samuele Fiorini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Veronica Tozzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Renzo Cordera
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Renzo Cordera.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the 1975 Declaration of Helsinki, as revised in 2008.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Managed by Antonio Secchi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bonabello, L.A., Maggi, D., Fiorini, S. et al. Switching from Glargine to Degludec is not associated with an overt change in glucose control in a cohort of patients with type 1 diabetes: a CGM analysis. Acta Diabetol 55, 637–639 (2018). https://doi.org/10.1007/s00592-018-1121-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00592-018-1121-3

Keywords

Search

Navigation