Anemia: an independent risk factor of diabetic peripheral neuropathy in type 2 diabetic patients
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Recently, the association between anemia and diabetic microvascular complications has been studied. Diabetic peripheral neuropathy (DPN) is also a common complication of type 2 diabetes mellitus (T2DM), while the relationship between anemia and DPN is rarely investigated. The aim of this study is to evaluate the association between anemia and DPN in T2DM.
In this cross-sectional study, 1134 T2DM inpatients were enrolled. The diagnosis of DPN was based on neuropathy system score (NSS) and neuropathy disability score (NDS). Logistic regression was conducted to analyze the association between anemia and DPN.
The proportions of anemia in DPN and non-DPN group were 25.4 and 15.2%, respectively. Compared with non-anemia group, the proportions of moderate/severe NSS (42.7 vs. 24.5%, P < 0.001) and moderate/severe NDS (51.5 vs. 38.0%, P < 0.001) were higher while the nerve conduction velocity (NCV) was lower in anemia group. Univariate logistic regression analysis showed patients with anemia possessed an increased risk of DPN [OR = 1.906, 95%CI: 1.416, 2.567, P < 0.001]. Multivariate logistic regression analysis suggested anemia was an independent risk factor of DPN in model 1 and model 2 [model 1: OR = 1.472, 95%CI: 1.047, 2.070, P = 0.026; model 2: OR = 1.448, 95%CI: 1.013, 2.071, P = 0.043].
Anemia is an independent risk factor of DPN in T2DM patients.
KeywordsDiabetic peripheral neuropathy Anemia Type 2 diabetes mellitus Microvascular complication
The authors thank the First Affiliated Hospital of Chongqing Medical University. This research was supported by National Key Clinical Specialties Construction Program of China (Grant Number: 2011-170) and National Natural Science Foundation of China Grants (Grant Number: 81200588). Rong Li has full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses.
Compliance with ethical standards
Conflict of interest
Fan Wu, Yuanyuan Jing, Xiaojun Tang, Dai Li, Lilin Gong, Hongyan Zhao, Li He, Qifu Li and Rong Li declare that they have no conflict of interest.
The ethical committee of Chongqing Medical University approved this study. The approved number is 20130024. All procedures followed were performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
Informed consent disclosure
Informed consent was obtained from all individual participants included in the study.
- 3.Charles M, Ejskjaer N, Witte DR, Borch-Johnsen K, Lauritzen T, Sandbaek A (2011) Prevalence of neuropathy and peripheral arterial disease and the impact of treatment in people with screen-detected type 2 diabetes: the addition-denmark study. Diabetes Care 34(10):2244–2249. doi: 10.2337/dc11-0903 CrossRefPubMedPubMedCentralGoogle Scholar
- 9.He BB, Xu M, Wei L et al (2015) Relationship between anemia and chronic complications in chinese patients with type 2 diabetes mellitus. Arch Iranian Med 18(5):277–283Google Scholar
- 15.Bansal D, Gudala K, Muthyala H, Esam HP, Nayakallu R, Bhansali A (2014) Prevalence and risk factors of development of peripheral diabetic neuropathy in type 2 diabetes mellitus in a tertiary care setting. J Diabetes Investig 5(6):714–721. doi: 10.1111/jdi.12223 CrossRefPubMedPubMedCentralGoogle Scholar