Serum ferritin, diabetes, diabetes control, and insulin resistance
- 358 Downloads
The present study aims to investigate the association between serum ferritin and diabetes, diabetes control, and insulin resistance (IR) and examine whether gender is a modifier for these associations in a community-based sample.
A cross-sectional survey of 8,235 participants was conducted in 2009. Serum ferritin, glucose, hemoglobin A1c (HbA1c), insulin, inflammatory markers, and lipid markers were measured. IR was estimated with a Homeostasis Model Assessment (HOMA-IR) equation. Multiple logistic and linear regression models were applied to evaluate these associations.
The numbers of diabetic patients and non-diabetic participants in the present study were 644 (7.8 %) and 7,591 (92.2 %). After adjusting for multiple confounders, the odds ratios (ORs) and 95 % confidence intervals (CIs) for diabetes were 1.48 (1.31–1.69) in men and 1.43 (1.24–1.65) in women for one-unit increase in log-transformed serum ferritin levels. Likewise, ORs (95 % CIs) for poor diabetes control (HbA1c ≥7.5 %) were 1.58 (1.21–2.05) and 1.37 (1.07–1.77) in men and women, respectively. As for HOMA-IR, the respective betas (P value) for one-unit increase in log-transformed serum ferritin were 0.07 (P < 0.0001) and 0.06 (P < 0.0001) in men and women.
In conclusion, elevated serum ferritin levels were associated with higher risks of diabetes, higher levels of HbA1c, and HOMA-IR independent of several confounders.
KeywordsFerritin Diabetes Insulin resistance Hemoglobin A1c
- 5.Dekker LH, Nicolaou M, van der AD, Busschers WB, Brewster LM et al (2013) Sex differences in the association between serum ferritin and fasting glucose in type 2 diabetes among South Asian Surinamese, African Surinamese, and ethnic Dutch: the population-based SUNSET study. Diabetes Care 36:965–971PubMedCentralPubMedCrossRefGoogle Scholar
- 13.Bd Benoist, Mclean E, Egli I, Cogswell M (eds) (2008) Worldwide prevalence of anaemia 1993–2005. World Health Organization, GenevaGoogle Scholar
- 21.Fumeron F, Pean F, Driss F, Balkau B, Tichet J et al (2006) Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Diabetes Care 29:2090–2094PubMedCrossRefGoogle Scholar
- 26.Batchuluun B, Matsumata T, Erdenebileg N, Tsagaantsooj G, Boldbaatar K et al (2014) Serum ferritin level is higher in poorly controlled patients with Type 2 diabetes and people without diabetes, aged over 55 years. Diabet Med 31:419–424Google Scholar