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Association of restrictive ventilatory dysfunction with the development of prediabetes and type 2 diabetes in Koreans

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Abstract

Aims

This study was performed to investigate whether ventilatory dysfunction is a predictor for the development of prediabetes and type 2 diabetes in Koreans.

Methods

We analyzed the clinical and laboratory data of 16,195 Korean adults (age 20–79 years) who underwent routine medical checkups with a mean 4.7-years (range 3.0–5.9 years) interval. Spirometry results were categorized into three patterns: normal, obstructive ventilatory dysfunction [OVD; forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.70], and restrictive ventilatory dysfunction (RVD; FVC < 80 % predicted, FEV1/FVC ≥ 0.70).

Results

Compared with subjects with normal ventilatory function, subjects with RVD had a higher incidence of type 2 diabetes (3.7 vs. 6.3 %; P < 0.001), whereas subjects with OVD did not (3.7 vs. 4.8 %; P = 0.119). On multivariate logistic regression analysis, the odds ratio (OR) of RVD for type 2 diabetes was significantly increased after adjusting for age, sex, and lifestyle factors (1.40; 95 % CI 1.10–1.78). However, further adjustment for body mass index (BMI), waist circumference, and baseline glucose level attenuated the OR to become insignificant (1.12; 95 % CI 0.86–1.47). Among the 9,461 participants who had normal fasting glucose and HbA1c levels at baseline, the OR for progression to prediabetes or diabetes in the RVD group was significantly increased (1.30; 95 % CI 1.12–1.51). The increased OR remained significant after adjusting for BMI, waist circumference, and baseline glucose level (1.26; 95 % CI 1.07–1.47).

Conclusions

Our results indicate that restrictive, but not obstructive ventilatory dysfunction, is independently associated with development of prediabetes and precedes the development of type 2 diabetes.

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Conflict of interest

Chul-Hee Kim, Hong-Kyu Kim, Eun-Hee Kim, Sung-Jin Bae, Young-Ju Jung, Jaewon Choi, and Joong-Yeol Park declare that they have no conflict of interest.

Statement of human and animal rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Statement of informed consent

Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea

    Chul-Hee Kim

  2. Health Screening and Promotion Center, Asan Medical Center, 388-1 Poongnap-dong, Songpa-ku, Seoul, 138-736, South Korea

    Hong-Kyu Kim, Eun-Hee Kim, Sung-Jin Bae, Young-Ju Jung & Jaewon Choi

  3. Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea

    Joong-Yeol Park

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  1. Chul-Hee Kim
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Correspondence to Hong-Kyu Kim.

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Kim, CH., Kim, HK., Kim, EH. et al. Association of restrictive ventilatory dysfunction with the development of prediabetes and type 2 diabetes in Koreans. Acta Diabetol 52, 357–363 (2015). https://doi.org/10.1007/s00592-014-0649-0

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  • DOI: https://doi.org/10.1007/s00592-014-0649-0

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