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Serum prolidase activity in diabetic foot ulcers

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Abstract

Impaired wound healing is an important problem in diabetes mellitus; however, its pathogenesis remains unclear. We aimed to evaluate serum prolidase activity (SPA), an important marker of collagen turnover, in subjects with and without diabetic foot ulcers as compared with healthy controls. Twenty-seven patients with diabetic foot ulcers (foot ulcer group), 27 patients without diabetic foot ulcers (diabetic control group) and 27 healthy controls were enrolled. The study groups had similar age, sex distribution and body mass index. Metabolic and inflammatory parameters as well as SPA were determined. The diabetic foot ulcer group had significantly higher SPA (both p < 0.001) when compared with the diabetic and the healthy control groups. SPA showed a positive correlation with high-sensitive C-reactive protein and a negative correlation with high-density lipoprotein cholesterol levels (r = 0.313, p = 0.021 and r = −0.233, p = 0.036, respectively). No correlation was detected between SPA and glycaemic parameters. SPA appears to be higher in patients with diabetic foot ulcers when compared with patients without diabetic foot ulcers and healthy controls. The underlying mechanisms of elevated SPA and its clinical significance in predicting the natural course of wound healing in diabetic foot ulcers needs to be further evaluation.

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Authors and Affiliations

  1. Department of Endocrinology, School of Medicine, Harran University, Sanliurfa, Turkey

    Mehmet Ali Eren, Ayse Nur Torun, Suzan Tabur & Tevfik Sabuncu

  2. Department of Internal Medicine, School of Medicine, Harran University, Sanliurfa, Turkey

    Turgay Ulas & Mehmet Demir

  3. Department of Clinical Biochemistry, School of Medicine, Harran University, Sanliurfa, Turkey

    Nurten Aksoy

  4. Department of Endocrinology, Faculty of Medicine, Harran University, Yenisehir Campus, 63300, Sanliurfa, Turkey

    Mehmet Ali Eren

Authors
  1. Mehmet Ali Eren
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  2. Ayse Nur Torun
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  3. Suzan Tabur
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  4. Turgay Ulas
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Correspondence to Mehmet Ali Eren.

Additional information

Communicated by Guido Pozza.

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Eren, M.A., Torun, A.N., Tabur, S. et al. Serum prolidase activity in diabetic foot ulcers. Acta Diabetol 50, 423–427 (2013). https://doi.org/10.1007/s00592-012-0448-4

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  • DOI: https://doi.org/10.1007/s00592-012-0448-4

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