The potential role of glutamate in the current diabetes epidemic

Abstract

In the present article, we propose the perspective that abnormal glutamate homeostasis might contribute to diabetes pathogenesis. Previous reports and our recent data indicate that chronically high extracellular glutamate levels exert direct and indirect effects that might participate in the progressive loss of β-cells occurring in both T1D and T2D. In addition, abnormal glutamate homeostasis may impact all the three accelerators of the “accelerator hypothesis” and could partially explain the rising frequency of T1D and T2D.

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Acknowledgments

This work was supported by University Research Program 2008 (to CP) and National Institutes of Health Grant RO1 DK080148 (to FF). AMD, CP, and FF and Eliana Sara di Cairano (ESDC) are inventors in a Patent Cooperation Treaty application (PCT/EP09/08256, US2011/0244486A1).

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Correspondence to Alberto M. Davalli.

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Davalli, A.M., Perego, C. & Folli, F.B. The potential role of glutamate in the current diabetes epidemic. Acta Diabetol 49, 167–183 (2012). https://doi.org/10.1007/s00592-011-0364-z

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Keywords

  • l-Glutamic acid
  • Glutamate toxicity
  • Monosodium glutamate
  • Obesity
  • Diabetes
  • Pancreatic β-cells