Acta Diabetologica

, Volume 49, Issue 5, pp 401–404 | Cite as

The coexistence of type 1 diabetes, MODY2 and metabolic syndrome in a young girl

  • Valeria CalcaterraEmail author
  • Miryam Martinetti
  • Alessandro Salina
  • Concetta Aloi
  • Daniela Larizza
Case Report


Even though autoantibodies to pancreatic islet cells are normally found in type 1 diabetes and insulin-resistance due to overweight is more reminiscent of type 2 diabetes, some studies have described β-cell antibodies also in maturity-onset diabetes of the young (MODY) and in type 2 diabetes. A 7-year-old girl was referred to our Unit for incidental hyperglycemia and family history of MODY2 and type 2 diabetes. Genetic evaluation confirmed mutation L134P in exon 4 of the glucokinase gene and a high HLA-risk of type 1 diabetes. During follow-up, she developed type 1 diabetes and overweight-induced metabolic syndrome. The coexistence of MODY, type 1 diabetes and overweight-induced metabolic syndrome confirms that diabetes subtype probably represents a continuum of immune and metabolic dysfunction modified by genetic factors.


MODY2 Type 1 diabetes Metabolic syndrome 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Valeria Calcaterra
    • 1
    Email author
  • Miryam Martinetti
    • 2
  • Alessandro Salina
    • 3
  • Concetta Aloi
    • 3
  • Daniela Larizza
    • 1
  1. 1.Department of PediatricsUniversity of Pavia and IRCCS Policlinico San Matteo FoundationPaviaItaly
  2. 2.Immunohematology and Transfusion CentreIRCCS Policlinico San Matteo FoundationPaviaItaly
  3. 3.Pediatric ClinicGenoaItaly

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