Skip to main content
Log in

Higher liver transaminase levels and oral hypoglycemic drug therapy failure in patients with type 2 diabetes: is iron the missing link?

  • Letter to the Editor
  • Published:
Acta Diabetologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Irace C, Rossetti M, Carallo C, Morano S, Vespertini V, Mandosi E, Maranghi M, Fiorentino R, Filetti S, Gnasso A (2011) Transaminase levels in the upper normal range are associated with oral hypoglycemic drug therapy failure in patients with type 2 diabetes. Acta Diabetol. doi:10.1007/s00592-011-0261-s

  2. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB (2009) The role of iron in type 2 diabetes in humans. Biochim Biophys Acta 1790:671–681

    Article  PubMed  CAS  Google Scholar 

  3. Mascitelli L, Pezzetta F, Goldstein MR (2009) Hyperinsulinaemia and iron perturbation in patients with type 2 diabetes. Int J Clin Pract 63:672

    Article  PubMed  CAS  Google Scholar 

  4. Tuomainen TP, Nyyssönen K, Salonen R, Tervahauta A, Korpela H, Lakka T, Kaplan GA, Salonen JT (1997) Body iron stores are associated with serum insulin and blood glucose concentration: population study in 1, 013 eastern Finnish men. Diabetes Care 20:426–428

    Article  PubMed  CAS  Google Scholar 

  5. Ford ES, Cogswell ME (1999) Diabetes and serum ferritin concentration among U.S. adults. Diabetes Care 22:1978–1983

    Article  PubMed  CAS  Google Scholar 

  6. Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB (2004) Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 291:711–717

    Article  PubMed  CAS  Google Scholar 

  7. Facchini FS, Saylor KL (2002) Effect of iron depletion on cardiovascular risk factors: studies in carbohydrate intolerant patients. Ann NY Acad Sci 967:342–351

    Article  PubMed  CAS  Google Scholar 

  8. Fernandez-Real JM, Penarroja G, Castro A, Garcia-Bragado F, Hernandez-Aguado I, Ricart W (2002) Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function. Diabetes 51:1000–1004

    Article  PubMed  CAS  Google Scholar 

  9. George DK, Goldwurm S, MacDonald GA, Cowley LL, Walker NI, Ward PJ, Jazwinska EC, Powell LW (1998) Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 114:311–318

    Article  PubMed  CAS  Google Scholar 

  10. Sumida Y, Nakashima T, Yoh T, Furutani M, Hirohama A, Kakisaka Y, Nakajima Y, Ishikawa H, Mitsuyoshi H, Okanoue T, Kashima K, Nakamura H, Yodoi J (2003) Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. J Hepatol 38:32–38

    Article  PubMed  CAS  Google Scholar 

  11. Valenti L, Fracanzani AL, Dongiovanni P, Bugianesi E, Marchesini G, Manzini P, Vanni E, Fargion S (2007) Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol 102:1251–1258

    Article  PubMed  CAS  Google Scholar 

  12. Sumida Y, Kanemasa K, Fukumoto K, Yoshida N, Sakai K, Nakashima T, Okanoue T (2006) Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis: a pilot study. Hepatol Res 36:315–321

    Article  PubMed  CAS  Google Scholar 

  13. Okuda M, Sasaki S, Kunitsugu I, Sakurai R, Yoshitake N, Hobara T (2011) Iron load and liver enzymes in 10- and 13-year-olds. J Pediatr Gastroenterol Nutr 52:333–338

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Luca Mascitelli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mascitelli, L., Goldstein, M.R. Higher liver transaminase levels and oral hypoglycemic drug therapy failure in patients with type 2 diabetes: is iron the missing link?. Acta Diabetol 48, 355–356 (2011). https://doi.org/10.1007/s00592-011-0282-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00592-011-0282-0

Keywords

Navigation