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Association between resistin gene −420 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis

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Abstract

Epidemiological studies on the association between the single nucleotide polymorphism (SNP) at −420 C/G (rs1862513) in the human resistin gene (RETN) and the risk of type 2 diabetes mellitus (T2DM) are conflicting. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Twelve studies with 5,935 cases and 5,959 controls were enrolled by searching the databases of Medline, EMBASE, and Cochrane. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The heterogeneity and publication bias were investigated. The main analysis indicated no significant association [for allelic model: OR = 0.97 (0.92–1.03); for additive model: OR = 0.95 (0.83–1.09); for recessive model: OR = 0.98 (0.86–1.12); for dominant model: OR = 0.95 (0.88–1.04)]. Overall, no significant heterogeneity was found. Subgroup analysis by race and source of controls indicated no significant association. In conclusion, the current meta-analysis did not observe any association between the polymorphism of RETN −420 C/G and the risk of T2DM. The study may help us further understand the genetics of T2DM. However, larger and prospective studies are warranted to confirm this finding.

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Fig. 1
Fig. 2

Abbreviations

BNP:

Brain natriuretic peptide

CI:

Confidence interval

OR:

Odds ratio

RETN:

Resistin gene

T2DM:

Type 2 diabetes mellitus

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Acknowledgments

This work was supported by the National Science Foundation of China (No. 30771805).

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Authors and Affiliations

  1. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, 150086, Nangang District, Harbin, China

    Ying Wen, Peng Lu & Ling Dai

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  1. Ying Wen
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  2. Peng Lu
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  3. Ling Dai
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Correspondence to Ying Wen.

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Wen, Y., Lu, P. & Dai, L. Association between resistin gene −420 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis. Acta Diabetol 50, 267–272 (2013). https://doi.org/10.1007/s00592-010-0247-8

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  • DOI: https://doi.org/10.1007/s00592-010-0247-8

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