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Interleukin-18 contributes more closely to the progression of diabetic nephropathy than other diabetic complications

Acta Diabetologica volume 49, pages 111–117 (2012)Cite this article

Abstract

Diabetic complication is comprised of a wide variety of pathophysiological factors involving proinflammatory cytokines, adipokines, and oxidative stress, among others. Each of these complications differs in their incidence and the stage of their occurrence. We examined cytokines and stress markers in 48 patients with type 2 diabetes mellitus and compared the difference of their contribution to pathogenesis between nephropathy and other diabetic complications. Hemoglobin A1c correlated with the level of low-density lipoprotein-cholesterol, and significantly elevated in the severe macroangiopathy group. Cystatin C increased in the severe microangiopathy groups but did not increase in the macroangiopathy group. The levels of interleukin 18 (IL-18), high-sensitive CRP (H-CRP), liver-type fatty acid binding protein, and 8-hydroxy-2-deoxyguanosine increased in the severe microangiopathy group. These data suggest the participation of proinflammatory signaling and oxidative stress in the progression of microangiopathy. In particular, IL-18 and H-CRP were significantly elevated only in the severe nephropathy group but did not significantly elevate in other complications. These data suggest another effect of IL-18 on glomerulus in addition to its proinflammatory effect. In conclusion, we propose that IL18 has a specific role that contributes more closely to the progression of diabetic nephropathy than other diabetic complications.

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Acknowledgments

This work was supported in part by the fund of 50th anniversary of the foundation of Nihon University School of Medicine in 2007.

Conflicts of interest statement

All authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamimachi, Itabashiku, Tokyo, 173-8610, Japan

    Takayuki Fujita, Yoshinobu Fuke, Chie Shimizu, Yuki Wada & Koichi Matsumoto

  2. Department of Diabetes and Metabolism, Nihon University School of Medicine, 30-1 Oyaguchi-Kamimachi, Itabashiku, Tokyo, Japan

    Norikazu Ogihara

  3. Department of Ophthalmology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamimachi, Itabashiku, Tokyo, Japan

    Yumi Kamura

  4. Department of Laboratory Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamimachi, Itabashiku, Tokyo, Japan

    Atsushi Satomura

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  1. Takayuki Fujita
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  2. Norikazu Ogihara
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  3. Yumi Kamura
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Correspondence to Takayuki Fujita.

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Fujita, T., Ogihara, N., Kamura, Y. et al. Interleukin-18 contributes more closely to the progression of diabetic nephropathy than other diabetic complications. Acta Diabetol 49, 111–117 (2012). https://doi.org/10.1007/s00592-010-0178-4

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  • DOI: https://doi.org/10.1007/s00592-010-0178-4

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